Postoperative analgesic effect of orally administrated nefopam after a total knee arthroplasty: a randomized controlled trial (NefPO) - 69HCL20_0111

Hospices Civils De Lyon0 个研究点目标入组 46 人开始时间: 2024年5月31日最近更新: 2024年8月21日

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•Patient over 18., Patient scheduled for primary PTG under spinal anesthesia, in the orthopedics department of the Croix-Rousse hospital., Patient with an American Society of Anesthesiology (ASA) score between I and III., Patient having agreed to take part in the study and having signed the informed consent form., Patient entitled to social security benefits., Patient willing to return for all study visits.

•Any contraindication for nefopam (known hypersensitivity, past medical history of seizures, urinary retention, benign prostate hyperplasia, angle glaucoma, ischemic cardiomyopathy waiting for revascularization, atrial fibrillation), Medical conditions known to influence the pharmacokinetics of nefopam (chronic kidney failure with Glomerular Filtration Rate (GFR) <30mL/min/1,73m2, liver failure, current treatment with rifampicin, carbamazepine, azoles fungicides, macrolides), Current treatment with benzodiazepines, anxiolytics, antidepressants, histamine H1 antagonists, neuroleptics, baclofen, thalidomide, barbiturates, Medical history of gastric or esophageal surgery., Phenylketonuria, Pregnancy or breastfeeding, Past use of oral nefopam

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