The Effect of NB-UVB on Interleukin-36 Levels in Psoriasis
- Conditions
- Psoriasis
- Interventions
- Device: NB-UVB
- Registration Number
- NCT03526705
- Lead Sponsor
- Cairo University
- Brief Summary
Psoriasis is an immune-mediated skin disease that affects 1-2 % of the population. Several cytokines have been found to be involved in the complex pathogenesis of this disease. Il- 36 is one of the cytokines sharing in psoriasis pathogenesis, as its levels are elevated in psoriatic plaques. Cathepsin G is known to activate Il- 36 and promote inflammation in psoriasis.NB-UVB is one of the important treatment modalities for psoriasis.
The aim of this study is to detect the effect of NB-UVB on the lesional levels of IL-36 in psoriasis.
- Detailed Description
25 psoriasis patients will receive 26 sessions of phototherapy (NB-UVB). Patients will receive 3 sessions per week. Tissue levels of IL-36 and Cathepsin G will be assessed in skin lesions before starting treatment and after completing the 26 sessions.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 25
- Patients with psoriasis vulgaris of both sexes
- Age between 18 and 60 years old.
- Pregnant females
- Patients receiving systemic treatment or topical treatment for psoriasis within the past two months.
- Patients having other dermatological diseases.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description nb-uvb NB-UVB psoriasis patients will receive 26 sessions of nb-uvb phototherapy
- Primary Outcome Measures
Name Time Method changes in Il-36 levels in 25 psoriasis patients after 26 sessions of NB-UVB 6 months primary
- Secondary Outcome Measures
Name Time Method changes in cathepsin G levels in 25 psoriasis patients after 26 sessions of NB-UVB psoriasis 6 months secondary