NCT04811911Unknown4 期
Evaluation of the Effect of Narrowband Ultraviolet B Versus Methotrexate on Serum TWEAK Level in Psoriasis
Aswan University Hospital1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2020年12月13日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Serum TWEAK in psoriasis
研究概览
简要总结
The aim of the study is to evaluate the effect of NB-UVB versus MTX on serum TWEAK level in psoriatic patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with moderate to severe plaque psoriasis of any age and gender.
排除标准
- •History of psoriasis treatment with systemic and biological agents prior to the study for at least 3 months.
- •Pregnancy and lactation.
- •Infections
- •Patients with chronic diseases: hepatic disorders, hematologic disease, chronic renal failure or cancer
研究组 & 干预措施
Narrowband ultraviolet B
Active Comparator
Patients will receive 8 sessions of NB-UVB per month for 3 successive months
干预措施: Narrowband ultraviolet B (Radiation)
Methotrexate group
Active Comparator
Patients will receive 25 mg/1ml of methotrexate vial per week for 3 successive months
干预措施: Methotrexate (Drug)
结局指标
主要结局
Serum TWEAK in psoriasis
时间窗: 3 months
Measurement of tumor necrosis factor weak inducer of apoptosis (TWEAK) "pg/ml"; in psoriatic patients before and after treatment with NB-UVB versus MTX in comparison with healthy individuals, using ELISA (enzyme-linked immunosorbent assay).
次要结局
- Treatment of psoriasis(3 months)
研究者
El Hassan Mohsen Mansour Mahmoud
Principal investigator
Aswan University Hospital
研究点 (1)
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