Exercise-related predictors of cardiac resynchronization therapy
Completed
- Conditions
- heart failure10082206
- Registration Number
- NL-OMON40869
- Lead Sponsor
- Maxima Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
heart failure NYHA class III
accepted for CRT, according to current guidelines
left ventricular ejection fraction < 35%
Exclusion Criteria
Myocardial infarction or unstable angina less than 3 months prior to inclusion
Clinical signs of decompensated heart failure
Ventricular tachycardia or ischemia during exercise
Intra cardiac shunts or congenital heart disease limiting exercise capacity
Orthopaedic, vascular, pulmonary, neuromuscular and other disease limiting exercise capacity in a way that performing exercise tests is not feasible
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Correlation between exercise-related central hemodynamic and extra-cardiac<br /><br>parameters at baseline and the response to CRT, using logistic regression.<br /><br>Response to CRT is defined as a decline in end systolic left ventricular volume<br /><br>of at least 15% and/or increase of left ventricular ejection fraction (LVEF) of<br /><br>> 5%. Potential central hemodynamic predictors are assessed by exercise<br /><br>echocardiography (mitral regurgitation, LV volumes and intraventricular<br /><br>dyssynchrony) and radial artery pulse contour analysis (cardiac output).<br /><br>Potential extra cardiac predictors include peak oxygen uptake, oxygen uptake<br /><br>efficiency slope and kinetics of recovery of skeletal muscle oxygenation after<br /><br>sub maximal exercise using Near Infrared Spectroscopy. </p><br>
- Secondary Outcome Measures
Name Time Method <p>None</p><br>