Comparison of Effectiveness Between the Combination of Lidocaine Sprayed at Laryngeal Inlet and on the Cuff of Endotracheal Tube Versus Intravenous Lidocaine for Reducing Cough During Extubation
- Conditions
- Reducing Cough During Extubation
- Interventions
- Registration Number
- NCT04090112
- Lead Sponsor
- Khon Kaen University
- Brief Summary
Coughing during extubation of endotracheal tube (ETT) is a common problem that leads to poor surgical results including hemodynamic change, rebleeding at the surgical wound and wound dehiscence. Recently, lidocaine has been introduced for reducing coughing during extubation. However, data comparing routes of lidocaine application are lacking, thus, this study compared the combination of lidocaine sprayed on laryngeal inlet and cuff of ETT versus intravenous lidocaine injection for efficacy in reducing coughing
- Detailed Description
A prospective randomized control trial was conduct with 164 patients. They were randomly allocated into Gr. A and B. Group A received four puffs of 10% lidocaine sprayed at the cuff of ETT and four puffs at laryngeal inlet whereas Gr. B received 15 mg/kg of 2% lidocaine intravenous injection prior to extubation. The same general anesthesia protocol was applied in all of the patients. Incidence and severity of cough during extubation was evaluated. Furthermore, incidence of 24-hour postoperative adverse events (including sore throat, dysphagia, and hoarseness) and hemodynamic response after extubation were analyzed.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 164
- patients who underwent elective surgery with American Society of Anesthesiologists physical status classifications of I and III
- patients having body mass index more than 35 kg/m2, high risk of aspiration, chronic smokers more than ten pack-years, chronic cough or recent upper respiratory infection, suspected difficult airway, retained ETT prior surgery, surgery at oral cavity, neck and thoracic region, operative time more than 120 minutes or less than 30 minutes, and history of lidocaine allergy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description the study group (Group A) 10% lidocaine sprayed Patients received four puffs of 10% lidocaine sprayed at the cuff of ETT and four puffs at laryngeal inlet Comparator group (Group B) 2% lidocaine intravenous Patients received 15 mg/kg of 2% lidocaine intravenous injection prior to extubation
- Primary Outcome Measures
Name Time Method Change in incidence of coughing the incidence was recorded during extubation and immediatly extubation Coughing event was recorded by blinded anesthesiologist
- Secondary Outcome Measures
Name Time Method Severity of coughing the severity was recorded during extubation and immediatly extubation the severity of cough was recorded by blinded anesthesiologist. Coughing level severity (16) was evaluated as 0 = no cough; 1 = slight cough, cough without obvious contraction of abdomen; 2 = moderate cough, strong and sudden contraction of the abdomen lasting less than 5 seconds; 3 = severe cough, strong and sudden contraction of the abdomen sustained more than 5 seconds
Incidence of postoperative sore throat the incidence was recorded within 24 hr after extubation Incidence of postoperative sore throat was recorded by two blinded anesthetist nurses . The numeric rating scale (0 = no, 10 = extreme) was used for evaluation of sore throat. If the numeric rating scale was more than 3, it was considered as a significant adverse event.
Incidence of dysphonia the incidence was recorded within 24 hr after extubation Incidence of dysphonia was recorded by two blinded anesthetist nurses .
Incidence of dysphagia the incidence was recorded within 24 hr after extubation Incidence of dysphagia was recorded by two blinded anesthetist nurses .
Trial Locations
- Locations (1)
Khon Kaen University
🇹🇭Khon Kaen, Thailand