Evaluation of the Impact of Laterality on Brain Activation During a Virtual Mirror Therapy Task in Healthy Subjects

Completed

• Conditions: Healthy
• Interventions: Device: Left virtual mirror therapy task; Device: Right virtual mirror therapy task

• Registration Number: NCT05793762
• Lead Sponsor: Centre Hospitalier Régional d'Orléans

Brief Summary

The aim of this study is to investigate the differences in brain activation in healthy subjects during virtual mirror therapy tasks, depending on the laterality of the task. It seems that mirror therapy-related brain activation is greater when the visual feedback represents the non-dominant hand. The aim of this study is to highlight brain activation profiles during the use of virtual mirror therapy according to the lateralization of the feedback.

Detailed Description

Stroke frequently leads to upper limb deficit. The recovery of motor skills depends on many factors including laterality. The literature shows that cerebral activation during motor tasks differs depending on whether one is right-handed or left-handed and whether one uses the dominant hand or not. These differences probably lead to different recovery mechanisms depending on the side of the lesion and the laterality. An imaging technique is particularly suitable for exploring these different mechanisms: fNIRS (Functional Near Infra Red Spectroscopy). This method allows (like fMRI) to study cerebral neurovascular coupling. It is based on the fact that an activated brain region increases its local blood flow. Oxygenated (HbO) and deoxygenated (HbR) hemoglobin absorb infrared light and it is then possible to identify the cerebral cortical regions involved in a given task. This technique therefore makes it possible to study cerebral activation under more ecological conditions than fMRI and is thus particularly suitable for exploring rehabilitation techniques.

This research aims to study and compare in healthy subjects, using an fNIRS apparatus, the brain regions involved in a virtual mirror therapy task according to the laterality of the task.

The investigations will be carried out by the principal investigator or by specialized technicians from the neurology functional exploration department.

The acquisition has a duration of 15 minutes, it begins with a rest period of 120 seconds, which corresponds to the baseline. two different tasks are performed during the acquisition for each subject:

* observation of visual feedback of the right hand (RVF)

* observation of visual feedback of the left hand (LVF)

The design is a block design, each task, which has a duration of 20 seconds, is carried out 10 times per acquisition. There is therefore a total of 20 tasks whose order will be randomized.

Before each acquisition, the movements of the right and left hands (finger flexion and extension) are recorded by a camera integrated in the virtual mirror therapy tool. Movements are performed at a frequency of 0.5 Hz which appears to be the optimal frequency for observing cortical activation using a metronome.

Between periods of movement, the subject is in a rest position for a period from 15 to 25 seconds.

The instructions given to each subject are to observe the visual feedback on the screen and not to perform any movement during the acquisition.

After recruiting the subjects, the study investigator will check the inclusion and exclusion criteria.

If the subject can integrate the protocol, the acquisition will then be planned.

On the day of the acquisition, the fNIRS acquisition helmet (Brite MKII) will be installed by a specialist technician and instructions will be given. The recording is then made.

Study Timeline

• Study First Submitted: 2023-03-08
• Study Start: 2023-03-09
• Study First Submitted QC: 2023-03-20
• Primary Completion: 2023-03-23
• Study Completion: 2023-03-23
• Study First Posted: 2023-03-31
• Status Verified: 2023-05
• Last Update Submitted: 2023-05-05
• Last Update Posted: 2023-05-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Age:18 to 60
• Right handed
• No neurological disease

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Exclusion Criteria

• Person under tutorship or curatorship
• Known allergy to components of the fNIRS device: neoprene

Read More

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Healthy participants	Left virtual mirror therapy task	30 right handed healthy participants aged between 18 and 60.
Healthy participants	Right virtual mirror therapy task	30 right handed healthy participants aged between 18 and 60.

Primary Outcome Measures

Name	Time	Method
Mean change in the concentration of oxyhemoglobin during the task	Baseline	Changes in the concentration of oxyhemoglobin during the task measured with fnirs device
Mean change in the concentration of deoxyhemoglobin during the task	Baseline	Changes in the concentration of deoxyhemoglobin during the task measured with fnirs device

Secondary Outcome Measures

Name	Time	Method
Compare the feelings of the subjects	Baseline	visual analog scale.
Compare the cortical regions involved during the different mirror therapy tasks	Baseline	visual analog scale.

Trial Locations

Locations (1)

CHR Orléans; 🇫🇷 Orléans, France