Variations of Hemispheric Lateralisation of Language Depending of Gender and Age.
试验速览
- 阶段
- 不适用
- 试验地点
- 1
研究概览
简要总结
The purpose of this study is to determine whether gender and age modify cerebral activations during a silent word generation functional Magnetic Resonance task.
详细描述
Introduction : The theory of a bipolar organization of language was revised in the light of neuroimaging results and language seems to be processed in a large scale cognitive network. The organization and function of this neural network may be modified by several factors including gender and age. There is some controversy about sex differences in language according to behavioural and neuroimaging studies :
- a small but significant difference favouring females was observed for language abilities.
- a greater bi hemispheric functional Magnetic Resonance Imaging (fMRI)activation was described in females during language tasks, but Frost et al found no differences during a language comprehension task according to gender.
Age differences were mainly studied in childhood, but no consistent functional imaging data on aging are available.
Objective : To study the influence of gender and age on cortical fMRI activations during a silent semantic task.
Subjects : 48 right-handed native French-speaking subjects were included in 4 groups of 12 according to age and gender : young female (YF), Young Male (YM), Old Female (OF), and Old Male (OM). Old subjects had no Alzheimer's disease or other dementia according to their MMS score (> 26) and NINCDS-ADRDA criteria.
研究设计
- 研究类型
- Observational
- 观察模型
- Defined Population
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •normal neurological examination
- •right handed (lateralization index greater or equal to 0.8)
- •Extra inclusion criteria for old subjects:
- •Mini Mental State > 26
- •no criteria for Alzheimer's disease (DSM IV and NINCDS-ADRDA)
排除标准
- •neurological or uncontrolled cardiovascular disease (past or present)
- •contraindicate for MRI