Can Intravenous Lidocaine Decrease the Minimal Inducing Dose of Etomidate?: A Randomized Placebo-controlled Dose-response Study.
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 100
- 主要终点
- changes in blood pressure and heart rate.
研究概览
简要总结
IV lidocaine administration can reduce the minimal amount of Etomidate and time for induction of anesthesia.
详细描述
The study was carried out in West China Hospital of Sichuan University, Chengdu, China. All the patients were informed in detail about the procedure and the medications they are going to get. Patients are well informed about the beneficial and possible hazards of the medicines and procedure. Patients are also informed that they can withdraw from the study at any time if they find it uncomfortable or harmful for them. Patients' written informed consent was obtained and registered for the permission from the Hospital's Ethics Board.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients scheduled for Elective Surgery,
- •age limit within 18-70 years,
- •American Society of Anaesthesiologists physical status classification I-II
排除标准
- •Adrenal Cortex disorder,
- •Neurologic disease,
- •Psychiatric disorders,
- •Allergic to Local anesthetic drugs,
- •Patients who have received sedatives,analgesics or opioids within the previous 24 hrs.
研究组 & 干预措施
Lidocaine 1mg/kg
Lidocaine 1mg/kg is given intravenously within 2 minutes. Then, Etomidate 2mg intravenously every 15 seconds is given until the complete loss of consciousness as detected as the complete loss of eyelash reflex.
干预措施: Lidocaine 1mg/kg (Drug)
Lidocaine 1.5mg/kg
Lidocaine 1.5mg/kg is given intravenously within 2 minutes. Then, Etomidate 2mg intravenously every 15 seconds is given until the complete loss of consciousness as detected as the complete loss of eyelash reflex.
干预措施: Lidocaine 1.5mg/kg (Drug)
Lidocaine 2mg/kg
Lidocaine 2mg/kg is given intravenously within 2 minutes. Then, Etomidate 2mg intravenously every 15 seconds is given until the complete loss of consciousness as detected as the complete loss of eyelash reflex.
干预措施: Lidocaine 2mg/kg (Drug)
Lidocaine 2.5mg/kg
Lidocaine 2.5mg/kg is given intravenously within 2 minutes. Then, Etomidate 2mg intravenously every 15 seconds is given until the complete loss of consciousness as detected as the complete loss of eyelash reflex.
干预措施: Lidocaine 2.5mg/kg (Drug)
结局指标
主要结局
changes in blood pressure and heart rate.
时间窗: 6 weeks
次要结局
未报告次要终点
研究者
Niharika Dhakal
Resident,Department of Anesthesiology
West China Hospital