CTRI/2021/05/033573已完成未知
Estimation of the levels of macrophage polarization markers - Nitric oxide, CD 163 and MicroRNA 21, in the saliva of healthy, gingivitis and periodontitis patients with and without diabetes mellitus; An analytical case control study
AKSHAYA J0 个研究点目标入组 52 人开始时间: 待定最近更新:
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 52
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
入选标准
- •Based on 2017 World Workshop on the Classification of Periodontal and Peri-implant diseases and conditions, co-presented by the American Academy of Periodontology (AAP) and the European Federation of Periodontology (EFP),
- •Inclusion criteria for Healthy group:
- •1.Pristine periodontal health:
- •i. No bleeding on probing.
- •ii. Normal gingival sulcus depth.
- •iii. Normal bone heights.
- •iv. Controlled modifying factors.
- •v. Controlled predisposing factors.
- •2.Clinical periodontal health (intact periodontium):
- •i. No or minimal bleeding on probing.
- •ii. Normal gingival sulcus depth.
- •iii. Normal bone heights.
- •iv. Controlled modifying factors.
- •v. Controlled predisposing factors.
- •Inclusion criteria for Gingivitis group:
- •i.Absence of CAL
- •ii.PPD < 3mm
- •iii.BOP present
- •Inclusion criteria for Stage III/IV Periodontitis:
- •According to the new classification scheme (Kornman and Tonetti et al, 2018).
- •1.Stage III:
- •i.Interdental clinical attachment loss at site of greatest loss >= 5mm.
- •ii.Radiographic bone loss extending to middle or apical third of root
- •iii.Tooth loss due to periodontitis <= 4 teeth.
- •iv.Probing depth >= 6mm.
- •v.Extent: Greater than 30% of teeth involved (Generalized)
- •2.Stage IV:
- •i.Interdental clinical attachment loss at site of greatest loss >= 5mm.
- •ii.Radiographic bone loss extending to middle or apical third of root
- •iii.Tooth loss due to periodontitis >= 5 teeth.
- •iv.Extent: Greater than 30% of teeth involved (Generalized)
- •Inclusion criteria for Type 2 Diabetes mellitus
- •1.Patients with HbA1c levels more than 8% will be taken for the study in the groups involving Diabetes. (According to American Diabetes Association guidelines 2018)
排除标准
- •1.Pregnant women
- •2.Pregnant and lactating women.
- •3.Habits like tobacco ,smoking
- •4.Patients with immunodeficiency disorders.
- •5.Patients with other systemic inflammatory conditions like sepsis, pneumonia, pleural effusion, intra-abdominal infections, inflammatory bowel disorders, inflammatory rheumatoid disorders, chronic kidney disease, cancers, atherosclerosis, COPD, asthma, HIV and hepatitis will be excluded from the study.
- •6.Patients with systemic diseases like hypertension
- •7.History of periodontal treatment within the previous 6 months.
- •8.History of antibiotic therapy in the past 3 months.
- •9.Subjects who are not willing to participate in the study
研究者
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