Comparison of the efficacy of two routes of misoprostol administration (sublingual and vaginal) for termination of second trimester pregnancy
- Conditions
- Pregnancy, childbirth and the puerperium.-
- Registration Number
- IRCT138807202576N1
- Lead Sponsor
- Tehran university of medical university
- Brief Summary
AbstractSend to:<br /> Arch Gynecol Obstet. 2013 May;287(5):937-40. doi: 10.1007/s00404-012-2652-4. Epub 2012 Dec 4.<br /> Sublingual versus vaginal misoprostol for cervical ripening before hysteroscopy: a randomized clinical trial.<br /> Tanha FD1, Salimi S, Ghajarzadeh M.<br /> Author information<br /> Abstract<br /> PURPOSE:<br /> To evaluate the efficacy of two routes of misoprostol (sublingual and vaginal) for cervical ripening before hysteroscopy.<br /> METHODS:<br /> One hundred and ten perimenopausal women who were referred to a tertiary hospital for surgical hysteroscopy enrolled in this double-blind randomized clinical trial. They were divided into two groups to receive 400 mg misoprostol either sublingually or vaginally 6 h before hysteroscopy. The duration of dilatation, Hegar number inserted into the cervix without resistance, and hysteroscopic and drug complications were recorded for all cases.<br /> RESULTS:<br /> Forty-nine women in sublingual and 51 in vaginal group participated in the study. Dilatation time was significantly lower in sublingual group (P < 0.001). Median Hegar number passed into the cervix without resistance was 5 in sublingual versus 4 in vaginal group (P = 0.002). Cramp followed by vomiting and diarrhea were the most common side effects of misoprostol in the sublingual group, while cramp followed by vomiting was the most frequent side effect in the vaginal group. Diarrhea was not reported in the vaginal group (P = 0.008).<br /> CONCLUSION:<br /> Sublingual route of misoprostol could be considered as an effective medication before surgical hysteroscopy in perimenopausal women.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 210
All pregnant women in their second trimester (14-28 weeks) who have been referred to Mirzakoochakkhan hospital for termination of pregnancy; willingness to participate in the study. Exclusion criteria: Allergic reaction to prostaglandin; HTN; Glaucoma; more than twice repeat caesarean section; prolong PPROM; adrenal insufficiency; Parity > 5
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Abortion without surgical intervention. Timepoint: 24 -48hour. Method of measurement: Trans vaginal sonography.
- Secondary Outcome Measures
Name Time Method There is no residue of pregnancy. Timepoint: 24-48 h. Method of measurement: Trans vaginal sonography.