Effect of Different Anesthetic Techniques for Isolated Systolic Hypertensive Patients of Abdominal Surgery on Postoperative Hospital Stay and morbidity---a Prospective, Randomized Study
Overview
- Phase
- Not Applicable
- Intervention
- remifentanil(Ultiva)
- Conditions
- Postoperative Complications
- Sponsor
- Peking University First Hospital
- Enrollment
- 180
- Locations
- 1
- Primary Endpoint
- Length of postoperative hospital stay
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
In General anesthesia, two main ways of pain control are used intra-operatively, one is opioids, the other is epidural. Many colleges prefer using epidural analgesia because it is potent and more effective , and also the benefits of stress block, less depression of breath. however, the epidural technique often causes more drop of blood pressure, especially in dehydrated patients. The investigators designed the trial to see if the benefit weigh out the potential risk of epidural in isolated hypertensive patients.
Investigators
ZhouYan
MD
Peking University First Hospital
Eligibility Criteria
Inclusion Criteria
- •adults aged 50-70 with isolated systolic hypertension .
Exclusion Criteria
- •age \< 50 yr, ASA grade IV, severe cardiac or pulmonary insufficiency (FEV1 \< 1 litre) , malignant hypertension, psychiatric illness (intake of psychiatric medication other than selective serotonin re-uptake inhibitors), diastolic blood pressure more than 110 mmHg. emergency surgery, coagulopathy, significant renal and hepatic dysfunction (creatinine \> 50% or liver enzymes \> 50% upper limit of normal values)
Arms & Interventions
patients with isolated systolic hypertension
patients combined with isolated systolic hypertension undergoing abdominal surgery
Intervention: remifentanil(Ultiva)
patients with isolated systolic hypertension
patients combined with isolated systolic hypertension undergoing abdominal surgery
Intervention: epidural infusing 2% lidocaine
Outcomes
Primary Outcomes
Length of postoperative hospital stay
Time Frame: 5 weeks
cardiovascular morbidity
Time Frame: 2 weeks
respiratory morbidity
Time Frame: 2 weeks
postoperative renal failure
Time Frame: 2 weeks