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Clinical Trials/NCT01884298
NCT01884298
Completed
Not Applicable

Effect of Different Anesthetic Techniques for Isolated Systolic Hypertensive Patients of Abdominal Surgery on Postoperative Hospital Stay and morbidity---a Prospective, Randomized Study

Peking University First Hospital1 site in 1 country180 target enrollmentJanuary 2011

Overview

Phase
Not Applicable
Intervention
remifentanil(Ultiva)
Conditions
Postoperative Complications
Sponsor
Peking University First Hospital
Enrollment
180
Locations
1
Primary Endpoint
Length of postoperative hospital stay
Status
Completed
Last Updated
12 years ago

Overview

Brief Summary

In General anesthesia, two main ways of pain control are used intra-operatively, one is opioids, the other is epidural. Many colleges prefer using epidural analgesia because it is potent and more effective , and also the benefits of stress block, less depression of breath. however, the epidural technique often causes more drop of blood pressure, especially in dehydrated patients. The investigators designed the trial to see if the benefit weigh out the potential risk of epidural in isolated hypertensive patients.

Registry
clinicaltrials.gov
Start Date
January 2011
End Date
December 2012
Last Updated
12 years ago
Study Type
Interventional
Study Design
Single Group
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

ZhouYan

MD

Peking University First Hospital

Eligibility Criteria

Inclusion Criteria

  • adults aged 50-70 with isolated systolic hypertension .

Exclusion Criteria

  • age \< 50 yr, ASA grade IV, severe cardiac or pulmonary insufficiency (FEV1 \< 1 litre) , malignant hypertension, psychiatric illness (intake of psychiatric medication other than selective serotonin re-uptake inhibitors), diastolic blood pressure more than 110 mmHg. emergency surgery, coagulopathy, significant renal and hepatic dysfunction (creatinine \> 50% or liver enzymes \> 50% upper limit of normal values)

Arms & Interventions

patients with isolated systolic hypertension

patients combined with isolated systolic hypertension undergoing abdominal surgery

Intervention: remifentanil(Ultiva)

patients with isolated systolic hypertension

patients combined with isolated systolic hypertension undergoing abdominal surgery

Intervention: epidural infusing 2% lidocaine

Outcomes

Primary Outcomes

Length of postoperative hospital stay

Time Frame: 5 weeks

cardiovascular morbidity

Time Frame: 2 weeks

respiratory morbidity

Time Frame: 2 weeks

postoperative renal failure

Time Frame: 2 weeks

Study Sites (1)

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