Effect of Different Anesthetic Techniques for Isolated Systolic Hypertensive Patients of Abdominal Surgery on Postoperative Hospital Stay and Morbidity

Not Applicable

Completed

• Conditions: Postoperative Complications
• Interventions: Drug: remifentanil(Ultiva); Drug: epidural infusing 2% lidocaine

• Registration Number: NCT01884298
• Lead Sponsor: Peking University First Hospital

Brief Summary

In General anesthesia, two main ways of pain control are used intra-operatively, one is opioids, the other is epidural. Many colleges prefer using epidural analgesia because it is potent and more effective , and also the benefits of stress block, less depression of breath. however, the epidural technique often causes more drop of blood pressure, especially in dehydrated patients. The investigators designed the trial to see if the benefit weigh out the potential risk of epidural in isolated hypertensive patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-01
• Primary Completion: 2012-12
• Study Completion: 2012-12
• Status Verified: 2013-06
• Study First Submitted: 2013-06-19
• Study First Submitted QC: 2013-06-21
• Last Update Submitted: 2013-06-21
• Study First Posted: 2013-06-24
• Last Update Posted: 2013-06-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 180

Inclusion Criteria

• adults aged 50-70 with isolated systolic hypertension .

Exclusion Criteria

• age < 50 yr, ASA grade IV, severe cardiac or pulmonary insufficiency (FEV1 < 1 litre) , malignant hypertension, psychiatric illness (intake of psychiatric medication other than selective serotonin re-uptake inhibitors), diastolic blood pressure more than 110 mmHg. emergency surgery, coagulopathy, significant renal and hepatic dysfunction (creatinine > 50% or liver enzymes > 50% upper limit of normal values)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
patients with isolated systolic hypertension	remifentanil(Ultiva)	patients combined with isolated systolic hypertension undergoing abdominal surgery
patients with isolated systolic hypertension	epidural infusing 2% lidocaine	patients combined with isolated systolic hypertension undergoing abdominal surgery

Primary Outcome Measures

Name	Time	Method
Length of postoperative hospital stay	5 weeks
cardiovascular morbidity	2 weeks
respiratory morbidity	2 weeks
postoperative renal failure	2 weeks

Trial Locations

Locations (1)

PKU 1st hospital; 🇨🇳 Beijing, Beijing, China