Effect of E171 (titanium dioxide) in the colo
- Conditions
- E171, Titanium dioxide, Gut inflammation, BiomarkerE171, Titanium dioxide, Darm inflammatie, Biomarker
- Registration Number
- NL-OMON20868
- Lead Sponsor
- Maastricht University
- Brief Summary
rrutia-Ortega, I.M., Garduño-Balderas L.G. , Freyre-Fonseca V., Delgado-Buenrostro N.L. , González-Robles A., Pedraza-Chaverri J., Hernandez-Pando R., Terrazas-Balderas L.I., van Loveren H., Chirino Y.I. (2016) E171 exposure exacerbates tumor formation in azoxymethane-induced colorectal cancer. Food and Chemical Toxicology.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 80
Healthy with a Body Mass Index (BMI) between 18-27, male or female
- Between 18-70 years old
- Alcohol abuse up to 6 months before participation in this research, i.e. more than 4 drinks on any single day and more than 14 drinks per week for men and more than 3 drinks on any single day and more than 7 drinks per week for women
- Current presence of any diseases related to the gastrointestinal tract, kidney, liver, heart or lungs
- Current presence of symptoms related to diseases of the gastrointestinal tract, i.e. vomiting, diarrhoea or constipation, and altered stool, such as blood in stool
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome parameters are differences in transcriptomic markers after consumption of food additive E171. These outcomes in humans will shed light on the relevance of markers identified in preclinical studies, and how the animal data on the risk of facilitation of tumour growth can be extrapolated to humans
- Secondary Outcome Measures
Name Time Method Secondary outcome parameters include inflammatory markers such as ROS in the rectal epithelium. These outcomes will help to understand the inflammatory mechanisms that may be indicative of the risk to developing colorectal cancer.