NCT03709771终止不适用
Novel Mechanisms and Predictors of VEGF Receptor Inhibitor- or Immune Checkpoint Inhibitor-Associated Hypertension and Cardiovascular Disease
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 2
- 试验地点
- 1
- 主要终点
- Change in Mean Blood Pressure
研究概览
简要总结
The purpose of this study is to understand the effect of vascular endothelial growth factor tyrosine kinase (VEGF) inhibitor, immune checkpoint-inhibitor (ICI), and combination treatment on blood pressure and blood vessel function.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female, age 40 - 75 years old
- •Diagnosis of cancer
- •Receiving VEGF inhibitor, ICI, or combination (VEGF inhibitor + ICI or combination ICI) treatment, or not receiving any treatment.
- •Normal blood pressure or blood pressure treated to < 140/90 mm Hg with ≤2 antihypertensive medications
排除标准
- •Presence of peripheral artery disease
- •History of a heart attack within 1 year
- •History of a stroke within 1 year
- •Life expectancy < 3 months
- •Women who are pregnant
- •Women who are nursing
结局指标
主要结局
Change in Mean Blood Pressure
时间窗: Baseline and 1 month
Mean 24 hour blood pressure from ambulatory 24 hour recording
次要结局
- Ratio of Post-treatment to Pre-treatment Change in Digital Pulse Amplitude(Baseline and 1 month)
研究者
Joshua Beckman
Professor
Vanderbilt University Medical Center
研究点 (1)
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