The effect of atorvastatin administration on the outcome of patients with traumatic brain injury

Phase 3

Recruiting

Conditions: Brain Injury.
Unspecified brain damage due to birth injury
P11.2

Registration Number: IRCT20210113050023N1

Lead Sponsor: Ahvaz University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 60

Inclusion Criteria

Patients with moderate (GCS = 9.13) and severe (GCS = 8.5) brain trauma injuries based on GCS score
Patients with size of brain contusions less than 30 CC according to the initial CT-scan of the brain
No history of statins
Patients who arrived at the hospital less than 10 hours after the injury
their legal representative (guardian or trustee) will be present to receive the consent

Exclusion Criteria

Patients with GCS scores of 4 and 3
Patients with Grade IV on primary brain scan or CT scan
Patients with severe damage to other internal organs or spinal cord injury
History of kidney or liver disease
Creatine>2.5 mg/dl
History of brain tumor, stroke
History of infection
Previous craniotomy
Pregnant and lactating women
Patients with systolic blood pressure less than 90 mm Hg
History of taking low-molecular-weight anticoagulants such as aspirin, wafarin, or heparin (7 days before hospitalization)

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The score calculated from the GOS benchmark in relation to the patient's life condition. Timepoint: Daily until 3 months later. Method of measurement: GOS criteria.;The score calculated from the DRS measurement criterion in relation to the patient's state of consciousness and function. Timepoint: Daily until 3 months later. Method of measurement: DRS criteria.

Secondary Outcome Measures