Efficacy of Intravenous Ibuprofen in Multimodal Pain Management After Open Abdominal Hysterectomy: A Randomised Trial
Overview
- Phase
- Phase 2
- Intervention
- Ibuprofen
- Conditions
- Post Operative Analgesia
- Sponsor
- Menoufia University
- Enrollment
- 152
- Locations
- 1
- Primary Endpoint
- Morphine consumption
- Status
- Active, not recruiting
- Last Updated
- 12 months ago
Overview
Brief Summary
The current research is designed to investigate the analgesic efficacy of intravenous ibuprofen on the postoperative analgesic requirements, pain intensity and other recovery parameters.
Detailed Description
The patients will be given general anaesthesia. Anaesthesia will be induced by propofol 1-2 mg/kg, and fentanyl 1-2 µg/kg. Endotracheal intubation will be facilitated by atracurium 0.5 mg/kg. Anaesthesia will be maintained by isoflurane in oxygen - air mixture. Transversus abdominis plane block will be performed at the end of the operation. A postoperative analgesic regimen according to group allocation will be started.
Investigators
Abd-Elazeem Abd-Elhameed Elbakry
Assistant professor
Menoufia University
Eligibility Criteria
Inclusion Criteria
- •American Society of anaesthesiologists physical status I to III.
- •Open abdominal hysterectomy operations
Exclusion Criteria
- •History of gastrointestinal bleeding.
- •History of intracranial haemorrhage.
- •Pregnancy and lactation.
- •Taking angiotensin converting enzyme(ACE) inhibitors or anticoagulation drugs.
- •Asthmatic, hepatic,renal or heart failure.
- •Abnormal platelet count.
Arms & Interventions
ibuprofen group
intravenous ibuprofen 800mg in 200 ml normal saline+IV paracetamol 1000mg+Transversus abdominis plane block
Intervention: Ibuprofen
Outcomes
Primary Outcomes
Morphine consumption
Time Frame: Postoperative up to 24 hours
mg
Secondary Outcomes
- Arterial oxygen saturation(Perioperative)
- End tidal carbon dioxide(Perioperative)
- Time of first ambulation(First postoperative 24 hours)
- Duration of hospital stay(Postoperative up to 4 weeks)
- Pain intensity(Postoperative up to 24 hours)
- Anaesthesia recovery time(Perioperative)
- Respiratory rate(Perioperative)
- Heart rate(Perioperative)
- Duration of post anaesthesia care unit stay(First postoperative 24 hours)
- Mean arterial blood pressure(Perioperative)