Efficacy of Intravenous Ibuprofen in Multimodal Pain Management After Open Abdominal Hysterectomy: A Randomised Trial
试验速览
- 阶段
- 2 期
- 状态
- 进行中（未招募）
- 入组人数
- 152
- 试验地点
- 1
- 主要终点
- Morphine consumption
研究概览
简要总结
The current research is designed to investigate the analgesic efficacy of intravenous ibuprofen on the postoperative analgesic requirements, pain intensity and other recovery parameters.
详细描述
The patients will be given general anaesthesia. Anaesthesia will be induced by propofol 1-2 mg/kg, and fentanyl 1-2 µg/kg. Endotracheal intubation will be facilitated by atracurium 0.5 mg/kg. Anaesthesia will be maintained by isoflurane in oxygen - air mixture. Transversus abdominis plane block will be performed at the end of the operation. A postoperative analgesic regimen according to group allocation will be started.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •American Society of anaesthesiologists physical status I to III.
- •Open abdominal hysterectomy operations
排除标准
- •History of gastrointestinal bleeding.
- •History of intracranial haemorrhage.
- •Pregnancy and lactation.
- •Taking angiotensin converting enzyme(ACE) inhibitors or anticoagulation drugs.
- •Asthmatic, hepatic,renal or heart failure.
- •Abnormal platelet count.
研究组 & 干预措施
ibuprofen group
intravenous ibuprofen 800mg in 200 ml normal saline+IV paracetamol 1000mg+Transversus abdominis plane block
干预措施: Ibuprofen (Drug)
结局指标
主要结局
Morphine consumption
时间窗: Postoperative up to 24 hours
mg
次要结局
- Arterial oxygen saturation(Perioperative)
- End tidal carbon dioxide(Perioperative)
- Time of first ambulation(First postoperative 24 hours)
- Duration of hospital stay(Postoperative up to 4 weeks)
- Pain intensity(Postoperative up to 24 hours)
- Anaesthesia recovery time(Perioperative)
- Respiratory rate(Perioperative)
- Heart rate(Perioperative)
- Duration of post anaesthesia care unit stay(First postoperative 24 hours)
- Mean arterial blood pressure(Perioperative)
研究者
Abd-Elazeem Abd-Elhameed Elbakry
Assistant professor
Menoufia University