Gastric and neural correlates of bloating

Completed

Conditions: Bloating
dyspepsia
10018012

Registration Number: NL-OMON42621

Lead Sponsor: Wageningen Universiteit

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 30

Inclusion Criteria

-Age: 18-40 years
-BMI: 18.5 - 25.0 kg/m2
-Healthy (as judged by the participant)
-On average consuming more than 1 unit of beer per month but less than 13 units per week.
-On average consuming more than 1 unit of soft drink per month but less than 13 units per week.
-Willing to be informed about incidental findings of pathology and approving of reporting this to their general physician.

Exclusion Criteria

-Drug use or medical conditions which may interfere with normal functioning of the digestive tract. -Drug use or medical conditions which may interfere with normal functioning of the circulatory system
-Drug use or medical conditions which may lead to unreliable fMRI results (including, but not limited to neurological conditions)
-Reported unexplained weight loss or weight gain of > 5 kg in the month prior to pre-study screening
-For women: having the intention to become pregnant, pregnancy during the last 6 months or lactating
- Smoking on average more than one cigarette/cigar a day
-Having a contra-indication to MRI scanning including, but not limited to, metal in the body and claustrofobia

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1) Gastric measures (MRI): Gastric volume, air and liquid gastric<br /><br>compartments. 2) Subjective ratings of fullness and bloating. 3) Changes in<br /><br>regional brain activity in brain regions associated with visceral perception<br /><br>and processing, as assessed with perfusion fMRI.</p><br>

Secondary Outcome Measures