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临床试验/NCT00384241
NCT00384241已完成不适用

Inflammatory Factors, Genes and Stress Induced Pressure Natriuresis in Youth

Augusta University1 个研究点 分布在 1 个国家目标入组 1,099 人开始时间: 2006年8月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
1,099
试验地点
1
主要终点
Change in Urinary Sodium Excretion (UNaV)

研究概览

简要总结

High blood pressure affects nearly one third of all individuals in the United States. If left untreated, it can lead to stroke, heart failure, heart attack, kidney failure, or blindness. For many people, the exact cause of high blood pressure is unknown, but it is believed that both genetic and environmental factors contribute to the development of the condition. The purpose of this study is to examine the importance of genetics, inflammation, and stress on the development of high blood pressure.

详细描述

High blood pressure is a complex condition that can be caused by many factors, including obesity, diet, genetics, or stress. Maintaining a healthy balance of sodium in the body is important for adequate blood pressure control. Some individuals experience sustained high blood pressure during periods of extended stress, combined with the inability to excrete enough sodium through urine to re-establish normal blood pressure levels. This type of stress-induced high blood pressure is related to interleukin-6 (IL-6), a protein that stimulates inflammation and immune responses. To determine the interaction between stress, inflammation, and genetics, this study will examine the role of IL-6 in regulating sodium levels and blood pressure in individuals undergoing stress. This information will be useful in determining new ways to evaluate risk factors for high blood pressure.

This study will examine previously collected DNA samples from young adults who participated in prior genetic studies. There will be no study visits for participants. IL-6, IL-6R, glycoprotein 130 (gp130), and C-reactive protein (CRP) genes will be analyzed in all samples; changes in plasma levels of IL-6 and CRP in response to stress will be examined in selected samples. The parents of participants will be asked to provide cheek swabs for additional DNA analysis.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

年龄范围
15 Years 至 19 Years(Child, Adult)
性别
All
接受健康志愿者

入选标准

  • Participated in two previous NIH funded studies HL073260, HL077230
  • Biological parents willing to participate in the study
  • African American or European origins

排除标准

  • Non-biological parents

结局指标

主要结局

Change in Urinary Sodium Excretion (UNaV)

时间窗: Baseline and 4 hour

The value of Stress induced UNaV as determined by delta UNaV = stress UNaV - baseline UNaV.

次要结局

  • The Effect of Change in Stress Induced IL-6 on Systolic Blood Pressure(baseline and 4 hours)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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