A Study of the Intestinal Microbiome in Patients with Cirrhosis

Not yet recruiting

• Conditions: Liver Cirrhosis

• Registration Number: NCT06808698
• Lead Sponsor: Yonsei University

Brief Summary

This study aims to establish a cohort for analyzing the gut microbiome of patients with liver cirrhosis and to identify factors that influence the prognosis of these patients.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-01
• Study First Submitted: 2025-01-22
• Study First Submitted QC: 2025-01-29
• Last Update Submitted: 2025-01-29
• Study First Posted: 2025-02-05
• Last Update Posted: 2025-02-05
• Study Start: 2025-06-01
• Primary Completion: 2025-12-01
• Study Completion: 2025-12-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1. Aged 19 years or older:
2. Patients visiting the hospital with liver cirrhosis.
3. Patients diagnosed with liver cirrhosis who can understand the information provided to them or their representatives and have voluntarily given written consent to participate in this study

Exclusion Criteria

1. Cases not meeting the inclusion criteria
2. Patients who refuse participation
3. Patients who have taken or been administered antibiotics within the past 2 weeks or are scheduled to take or receive antibiotics during the study period
4. Cases where the diagnosis is unclear
5. Cases with incomplete data or missing investigation items
6. Individuals deemed unsuitable by the principal investigator for other reasons

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence rate of non-targeted complications according to changes in the gut microbiome	baseline, Month 12	We observed changes in the gut microbiome of the subjects participating in the study at baseline and 12 months, and confirmed the incidence of non-target complications accordingly.

Secondary Outcome Measures

Name	Time	Method
Liver cancer incidence rate according to gut microbiome composition	Baseline, 12 Month	We observed changes in the gut microbiome of the subjects participating in the study at baseline and 12 months, and confirmed the liver cancer incidence rate accordingly.