Does isocapnic hyperventilation hasten early recovery with sevoflurane and desflurane in O2/air?
Phase 1
- Conditions
- The absence of hypocapnia on the moment of emergence from general inhalatory anesthesiaTherapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]
- Registration Number
- EUCTR2014-000678-20-BE
- Lead Sponsor
- Z Brussel
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
> 18 years
ASA I & II patiënts
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 70
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 10
Exclusion Criteria
- Pulmonary hypertension
- Patients with evidence of coronary (NYHA III) disease
- Pulmonary disease (COPD/Asthma)
- Right ventricle dysfunction
- Psychiatric pathology like syndromes: dementia, schizophrenia, bipolar personality
- Daily use of benzodiazepines and/or opioids
- Use of psychogenic drugs
- Laparoscopies (Abdominal CO2 administration can bias our results)
- Pregnant women and breastfeeding women
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: The goal of the study is to examine the effect of hyperventilation on early recovery parameters when sevoflurane or desflurane is used. CO2 will be added to the inspired gas to avoid hypocapnia (isocapnic hyperventilation”);Secondary Objective: Decrease the length of stay in operating room and hospital.;Primary end point(s): Emergence time from general inhalatory anesthesia after hyperventilation when carbondioxide(CO2) was administrated to maintain alveolar isocapnia.;Timepoint(s) of evaluation of this end point: Opening of the eyes and presence of adequate voluntary minute ventilation.
- Secondary Outcome Measures
Name Time Method Secondary end point(s): Perfect statement of their date of birth;Timepoint(s) of evaluation of this end point: The moment of this act