The effect of increasing pulmonary ventilation in methanol poisoning
Phase 2
- Conditions
- Toxic alcohols.Toxic effect of methanolT51.1
- Registration Number
- IRCT20120629010133N5
- Lead Sponsor
- Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Adult patients, men & women diagnosed with methanol poisoning
Serum methanol = 50mg/dL
pH = 7.0, correctable by bicarbonate infusion
no visual disturbances
Exclusion Criteria
Acidosis requiring haemodialysis
Comatose patients
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change in methanol elimination kinetics (half-life and estimated clearance) when iHV is utilized. Timepoint: Hourly before intervention, and 1-2 hourly post intervention till 24 hours. Method of measurement: Measuring serum/urine methanol, formate.
- Secondary Outcome Measures
Name Time Method Score of iHV machine tolerability. Timepoint: Hourly. Method of measurement: Qualitative interview.;Score of feasibility of iHV machine. Timepoint: Hourly. Method of measurement: Likert's scale.;Implementation of fomepizole in Iran. Timepoint: End of trial. Method of measurement: Likert's scale.;Length of ICU- and hospital stay during treatment with iHV. Timepoint: End of trial. Method of measurement: Time frame of hospital stay.;Death. Timepoint: End of trial. Method of measurement: Yes or No.;Need for haemodialysis. Timepoint: hourly. Method of measurement: Yes or No.;Adverse Events. Timepoint: hourly. Method of measurement: Yes or No.