Measurement of changes in ventilation at various levels of inspired carbon dioxide with two methodes.
Completed
- Conditions
- healthy subjects
- Registration Number
- NL-OMON28684
- Lead Sponsor
- Eijsvogel, M.M.M.; Enschede; The Netherlands
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
healthy, adult aged between 18 and 65
Exclusion Criteria
history of cardio-pulmonary disease, neuro(muscular) disease, and/or kyphoscoliosis; unable to understand and read the English or Dutch language; drug abuse; use of respiratory stimulants or depressant; and pregnant women
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The main study endpoint is the reproducibility of the measurements. Sensitivity slope (L/min per kPa) of the curve is calculated by means of linear regression. To assess the repeatability of both methods, the ICC is calculated between the paired CO2 sensitivity slopes of the first and second rebreathing measurement and between the first and second steady-state measurement
- Secondary Outcome Measures
Name Time Method Secondary endpoints are: -The experiences of the subjects with both measurements - Duration of the measurements - Costs of the method (sum of the costs of the various part of each method + costs of one long function analyst performing the measurement) - minimal CO2 in rebreathing technique