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Clinical Trials/NCT06095609
NCT06095609
Completed
Not Applicable

The Implementation of Early Mobilization and Chest Physiotherapy on Weaning Rate of Prolong Weaning Patients. A Retrospective Study

Taoyuan General Hospital1 site in 1 country202 target enrollmentJune 1, 2022

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Prolonged Weaning, Early Mobilization, Chest Physiotherapy
Sponsor
Taoyuan General Hospital
Enrollment
202
Locations
1
Primary Endpoint
Weaning success rate
Status
Completed
Last Updated
2 years ago

Overview

Brief Summary

Weaning from mechanical ventilator is essential to liberate patients to normal life. Prolong weaning is defined as failure of 3 times spontaneous breath trial (SBT) and requiring more than 7 days weaning from mechanical ventilation after first SBT. higher unsuccessful rate of extubation and higher mortality rate. Possible reasons to cause prolong weaning could be attributed to intensive care unit acquired weakness (ICU-AW) and poor lung hygiene. In order to solve these two problems and increase the weaning rate, early mobilization (EM) and chest physiotherapy (CPT) are considered as possible strategy to attain the goal. According to previous articles, lacking of control group and small sample size made it difficult to confirm the true effect of EM and CPT on prolong weaning patients. Thus, the aims of this articles are discussing the influence from EM with CPT on weaning rate and other hospitalization outcomes with larger sample sizes and control group.

Registry
clinicaltrials.gov
Start Date
June 1, 2022
End Date
June 19, 2022
Last Updated
2 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
Taoyuan General Hospital
Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • The subjects' data which met the inclusion criteria are:
  • Patient with or without
  • Patient who met the criteria of received physiotherapy (Figure 1.)
  • No usage of life support device such as ECMO and so on.
  • Continuous mechanical ventilator use over 21 days.

Exclusion Criteria

  • The exclusion criteria are
  • Patients diagnosed as brain death
  • Patients who were ventilator dependent before admission
  • Patients who were against advice discharge under critical condition.
  • Patients received emergency intervention during course.
  • Patient who didn't meet the criteria of received physiotherapy (Figure 1.).

Outcomes

Primary Outcomes

Weaning success rate

Time Frame: up to 6 weeks in respiratory care center

Weaning success was defined as patients being free from MV or BiPAP for 5 days based on Taiwan

Secondary Outcomes

  • RCC mortality rate(up to 6 weeks in respiratory care center)
  • discharge to home rate(after 6 weeks in respiratory care center)
  • hospital mortality rate(up to 6 weeks in respiratory care center)
  • total mechanical ventilator use(up to 6 weeks in respiratory care center)
  • total hospital days of stay(up to 10 weeks in the hospital)
  • RCC days of stay(up to 6 weeks in respiratory care center)

Study Sites (1)

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