The Implementation of Early Mobilization and Chest Physiotherapy on Weaning Rate of Prolong Weaning Patients.

Not Applicable

Completed

• Conditions: Prolonged Weaning, Early Mobilization, Chest Physiotherapy

• Registration Number: NCT06095609
• Lead Sponsor: Taoyuan General Hospital

Brief Summary

Weaning from mechanical ventilator is essential to liberate patients to normal life. Prolong weaning is defined as failure of 3 times spontaneous breath trial (SBT) and requiring more than 7 days weaning from mechanical ventilation after first SBT. higher unsuccessful rate of extubation and higher mortality rate. Possible reasons to cause prolong weaning could be attributed to intensive care unit acquired weakness (ICU-AW) and poor lung hygiene. In order to solve these two problems and increase the weaning rate, early mobilization (EM) and chest physiotherapy (CPT) are considered as possible strategy to attain the goal. According to previous articles, lacking of control group and small sample size made it difficult to confirm the true effect of EM and CPT on prolong weaning patients. Thus, the aims of this articles are discussing the influence from EM with CPT on weaning rate and other hospitalization outcomes with larger sample sizes and control group.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-06-01
• Primary Completion: 2022-06-18
• Study Completion: 2022-06-19
• Study First Submitted: 2022-06-20
• Status Verified: 2022-09
• Study First Submitted QC: 2023-10-18
• Last Update Submitted: 2023-10-18
• Study First Posted: 2023-10-23
• Last Update Posted: 2023-10-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 202

Inclusion Criteria

• The subjects' data which met the inclusion criteria are: 1. Age>20 2. Patient with or without 3. Patient who met the criteria of received physiotherapy (Figure 1.) 4. No usage of life support device such as ECMO and so on. 5. Continuous mechanical ventilator use over 21 days.

Exclusion Criteria

• The exclusion criteria are 1. Patients diagnosed as brain death 2. Patients who were ventilator dependent before admission 3. Patients who were against advice discharge under critical condition. 4. Patients received emergency intervention during course. 5. Patient who didn't meet the criteria of received physiotherapy (Figure 1.).

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Weaning success rate	up to 6 weeks in respiratory care center	Weaning success was defined as patients being free from MV or BiPAP for 5 days based on Taiwan

Secondary Outcome Measures

Name	Time	Method
RCC mortality rate	up to 6 weeks in respiratory care center	the mortality rate of respiratory care center
discharge to home rate	after 6 weeks in respiratory care center	The rate of going home after discharge
hospital mortality rate	up to 6 weeks in respiratory care center	the mortality rate during the hospital course
total mechanical ventilator use	up to 6 weeks in respiratory care center	The days of mechanical use during the admission time
total hospital days of stay	up to 10 weeks in the hospital	The days staying in the hospital
RCC days of stay	up to 6 weeks in respiratory care center	The days staying in respiratory care center

Trial Locations

Locations (1)

Taoyaun General Hospital, Ministry of Wealth and Health; 🇨🇳 Taoyuan, Taoyuan Dist., Taiwan