Air Purifier to Improve Endothelial Function and Carotid Intima Thickness

Not Applicable

Completed

• Conditions: Cognitive Impairment; Endothelial Function
• Interventions: Device: Air purifier

• Registration Number: NCT03301402
• Lead Sponsor: Chinese University of Hong Kong

Brief Summary

Background: There is epidemiological evidence or link ambient air pollution exposure to the incidence of dementia.

Aims or hypotheses: It is hypothesized that reduction in indoor pollutants from air purification improves endothelial function and carotid intima thickness in older diabetic people with cognitive impairment.

Subjects and method: People with clinically diagnosis mild cognitive impairment or early dementia will be recruited. After obtaining written consent, the subjects will be assessed cognitive function and arterial health. After baseline measurements, the subjects are randomly assigned to have either filter or no filter installed in the air purifier. The air purifier will be placed in living room of the household of the subject for one year. At one year, the measurements will be repeated.

Statistical analysis: Intention to treat analysis will be adopted.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-09-22
• Study First Submitted: 2017-09-28
• Study First Submitted QC: 2017-10-03
• Study First Posted: 2017-10-04
• Primary Completion: 2021-01-05
• Study Completion: 2021-01-05
• Status Verified: 2021-05
• Last Update Submitted: 2021-05-28
• Last Update Posted: 2021-06-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 61

Inclusion Criteria

• Diabetic people
• Mild cognitive impairment or early dementia

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Exclusion Criteria

• Current smoker
• The presence of a smoker in the household
• The absence of a reliable family caregiver
• The lack of mental capacity to give informed consent

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Filter	Air purifier	-

Primary Outcome Measures

Name	Time	Method
FMD%	12 months	Endothelial function will be assessed by Flow mediated dilatation of brachial artery

Trial Locations

Locations (1)

The Chinese University of Hong Kong; 🇭🇰 Hong Kong, Hong Kong