Substrate Oxidation Does Not Affect Short Term Food Intake in Healthy Boys and Men

Not Applicable

Completed

• Conditions: Food Intake Regulation; Substrate Oxidation
• Interventions: Other: Glucose Preload and Exercise Intervention

• Registration Number: NCT01888991
• Lead Sponsor: University of Toronto

Brief Summary

The purpose of this study is to investigate the effect of substrate oxidation, expressed by RER, on food intake regulation and net energy balance.

Detailed Description

The relationship between substrate oxidation as measured by respiratory exchange ratio (RER) and food intake is undefined. This study is examining the effects of three modulators of substrate oxidation (RER), a glucose preload, exercise and age food intake regulation and net energy balance in normal-weight boys (9-12 y) and men (20-30 y).

Subjects (15 boys, 15 men) were measured in random order with treatments of beverages of either water or glucose followed by either moderate exercise or rest for 40 min. Measures included RER via indirect calorimetry, energy expenditure, subjective appetite, food intake measured at an ad libitum pizza meal and net energy balance as the sum of the calories of the glucose preload + calories from the pizza lunch minus energy expended at exercise or rest.

Study Timeline

• Study Start: 2011-12
• Primary Completion: 2012-08
• Study Completion: 2012-08
• Status Verified: 2013-06
• Study First Submitted: 2013-06-22
• Study First Submitted QC: 2013-06-25
• Last Update Submitted: 2013-06-25
• Study First Posted: 2013-06-28
• Last Update Posted: 2013-06-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 30

Inclusion Criteria

• Born at full term
• Men Age:20-29 years/BMI: 20-25
• Boys Age 9-11/BMI percentile: 15th to 85th:

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Exclusion Criteria

• Smokers
• Dieters
• Individuals with lactose intolerance, allergies to milk and dairy products
• Individuals with gastrointestinal problems
• Individuals with diabetes or other metabolic diseases
• Individuals scoring ≥ 11 on an Eating Habit Questionnaire

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
glucose with resting condition	Glucose Preload and Exercise Intervention	-
water with exercise condition	Glucose Preload and Exercise Intervention	-
glucose with exercise condition	Glucose Preload and Exercise Intervention	-

Primary Outcome Measures

Name	Time	Method
Food Intake	60 - 90 min in the study	Energy intake from the ad libitum the pizza meal at 60 min was calculated based on the weight consumed and the compositional information provided by the manufacturer.

Secondary Outcome Measures

Name	Time	Method
Net Energy Balance	0-90 min in the study	Will be calculated from the energy consumed by the glucose preload and the pizza meal minus energy expended at the exercise.

Trial Locations

Locations (1)

Department of Nutritional Sciences, University of Toronto; 🇨🇦 Toronto, Ontario, Canada