Recruitment Maneuver After Bronchoalveolar Lavage in ARDS Patients
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 40
- Primary Endpoint
- the ratio of tidal volume in the BAL side and the other side
Study Overview
Brief Summary
ARDS caused by pneumonia is one of the main reasons for ICU admission in critically ill patients, and also a common complication in patients admitted to ICU with invasive mechanical ventilation. Bronchoalveolar lavage (BAL) is the main diagnostic method for these patients, which often leads to alveolar collapse and exacerbates hypoxemia. In clinical practice, recruitment maneuver (RM) is often used immediately after BAL to prevent such a situation, but there is a lack of data on RM after BAL.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Other
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Adult patients with invasive mechanical ventilation;
- •Patients who diagnosed with ARDS according to the Berlin definition
- •There are indications for bronchoalveolar lavage
Exclusion Criteria
- •Patients with contraindications for EIT procedures;
- •Patients with contraindications for RM;
- •Previous chronic respiratory diseases (long-term home oxygen therapy for chronic respiratory diseases such as pulmonary fibrosis or COPD);
- •Refusal to sign informed consent
Arms & Interventions
RM after BAL
patients underwent RM after BAL
Intervention: Recruitment Maneuver (Other)
Non-RM after BAL
patients did not undergo RM after BAL
Outcomes
Primary Outcomes
the ratio of tidal volume in the BAL side and the other side
Time Frame: up to 24 hours
distribution of tidal volume monitored by electrical impedance tomography from the BAL side to the other side
Secondary Outcomes
- respiratory system compliance (the tidal volume to the driving pressure ratio)(up to 24 hours)
- partial pressure of arterial oxygen (Pao2) to the fraction of inspired oxygen (Fio2) ratio(up to 24 hours)
Investigators
Ling Liu
Director of Intensive Care Unit, Principal Investigator, Clinical Professor
Southeast University, China