NCT02020395已完成1 期
Effect of a Test Meal on Satiation Hormones in Obese and Normal Weight Adolescents
University Hospital, Basel, Switzerland2 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2009年6月1日最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Comparison of gastrointestinal peptide secretion in normal weight and obese adolescents
研究概览
简要总结
The objective of this study is to examine ghrelin, amylin, glucagon and glucagon-like peptide (GLP)-1 responses to a test meal in lean and obese individuals.
详细描述
The primary hypothesis is that obese adolescents have a disturbed balance of hormones associated with appetite regulation with less suppression of ghrelin and attenuated stimulation of GLP-1 secretion in response to meal intake compared to lean normal weight controls. A second aim of the study was to test which gastrointestinal peptides are most associated with insulin resistance.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 11 Years 至 16 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •caucasian youth
- •pubertal Tanner stage x, y, or z
排除标准
- •fasting plasma glucose > 7.0 mmol/L
- •significant illness
- •taking medications
结局指标
主要结局
Comparison of gastrointestinal peptide secretion in normal weight and obese adolescents
时间窗: 2 hours blood sampling
Relation of GLP-1 release to insulin secretion in normal weight and obese adolescents
次要结局
- Association between gastrointestinal peptides and insulin release(2 hours blood sampling)
研究者
研究点 (2)
Loading locations...
相似试验
已完成
不适用
Gut Hormone Response, Appetite and Intestinal Transit Time in Good and Poor Weight Responders After Gastric BypassObesityNCT00908973Hvidovre University Hospital46
已完成
不适用
Influence of Gut Hormones on Food Intake After Roux-en-Y Gastric Bypass SurgerySevere ObesityNCT02336659Hvidovre University Hospital12
招募中
不适用
Impact of Macronutrient Composition of Energy-restricted Diet and Exercise on Body Composition and Appetite Hormones.Gastrointestinal HormonesNCT06022315University of Glasgow40
Unknown
不适用
Long Term Effects of Weight Loss on Post-prandial Gut Hormone Responses and Meal Induced ThermogenesisMorbid ObesityNCT04170010National and Kapodistrian University of Athens45
已完成
不适用
Oral Glucose Stimulation in Normal-weight and Obese VolunteersEndocrine System DiseasesNCT01875575University Hospital, Basel, Switzerland24