YKL-40 and IL-6 Levels in Periodontal Disease
- Conditions
- Periodontal Diseases
- Interventions
- Procedure: Nonsurgical periodontal therapy
- Registration Number
- NCT03507868
- Lead Sponsor
- Zeynep Pinar KELES
- Brief Summary
The primer aim of the study was to investigate saliva and gingival crevicular fluid (GCF) YKL-40 and also interleukin-6 (IL-6) levels in chronic periodontitis pathogenesis.
- Detailed Description
This study consisted of two groups: 26 periodontally healthy individuals and 26 generalized chronic periodontitis patients. Chronic periodontitis patients were received nonsurgical periodontal treatment. Clinical measurements were recorded, saliva and GCF samples were obtained before and at first and third months after periodontal therapy. Levels of YKL-40 and IL-6 in saliva and GCF were analyzed by enzyme-linked immunosorbent assay.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 52
Group 1 Inclusion Criteria:
- No bone and attachment loss,
- GI=0, PPD≤3mm, CAL≤3mm
- Systematically healthy patients
Group 2 Inclusion Criteria:
- GI>1, PPD≥5mm, CAL≥5mm with alveolar bone loss radiographically.
- Systematically healthy patients
- Aggressive Periodontitis,
- Patients with any other systemic diseases,
- Pregnant women and those in the lactation period,
- Patients with smoking habit and taking medication
- Patients received periodontal therapy in last 6 month
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Group 2 Nonsurgical periodontal therapy Chronic periodontitis patients
- Primary Outcome Measures
Name Time Method YKL-40 levels at first and third month after therapy changes in YKL-40 levels after periodontal therapy
- Secondary Outcome Measures
Name Time Method IL-6 levels at first and third month after therapy changes in IL-6 levels after periodontal therapy