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Clinical Trials/NCT01560611
NCT01560611
Unknown
Not Applicable

The Somatic-to-cerebral Oxygen Saturation Gradient as a Non-invasive Index of Anaerobic Threshold in High-risk Cardiac Surgical Patient

University Hospital, Strasbourg, France1 site in 1 country60 target enrollmentMarch 2012

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Cardiac Surgical Procedures
Sponsor
University Hospital, Strasbourg, France
Enrollment
60
Locations
1
Last Updated
14 years ago

Overview

Brief Summary

In patients undergoing cardiac surgery under cardiopulmonary bypass, some organs like brain and heart are preserved while others (skin, gut and skeletal muscle) are being underperfused. This phenomenon is related to silent peripheral vasoconstriction that is not clinically available but threatens end-organ perfusion and carries the risk of multi-organ failure. By measuring non-invasively the somatic-to-cerebral oxygen saturation gradient, the present study aims at detecting silent peroperative hypoperfusion episodes. The investigators hypothesize that gradient, measured during the surgical procedure, will predict the occurrence of anaerobic metabolism, ascertained by an elevation of blood lactate concentration, measured in intensive care unit.

Registry
clinicaltrials.gov
Start Date
March 2012
End Date
TBD
Last Updated
14 years ago
Study Type
Observational
Sex
All

Investigators

Sponsor
University Hospital, Strasbourg, France
Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Age \> 18 yo
  • Cardiac surgical procedure under cardiopulmonary bypass
  • High-risk surgical patient fulfilling one of the following items:
  • Euroscore \>= 6
  • Ejection fraction \< 40%
  • Creatinine clearance \< 40mL/min
  • Pulmonary arterial pressure \> 45mmHg
  • Signed informed consent
  • Social security affiliation

Exclusion Criteria

  • Emergency situation
  • Patient on ECMO
  • Pregnancy or lactation

Outcomes

Primary Outcomes

Not specified

Study Sites (1)

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