Hemodynamic Effects of Negative Pressure Ventilation in Chronic Obstructive Pulmonary Disease

Completed

• Conditions: COPD
• Interventions: Other: Received negative pressure ventilation

• Registration Number: NCT04212559
• Lead Sponsor: Fu Jen Catholic University

Brief Summary

Negative pressure ventilation (NPV) is a non-invasive ventilation mode which provide better lung expansion. The major complication of NPV is decrease blood pressure and affects the hemodynamics. The effects of NPV on chronic obstructive pulmonary disease (COPD) patients with pulmonary rehabilitation program remains unknown.

Detailed Description

Both of NPV or positive pressure ventilation (PPV) has impact of hemodynamics. NPV with cuirass ventilator increases venous return and leads to ventricular filling and increases cardiac output (CO); In contrast to NPV, the effect of PPV in most situations is a decreased venous return and leads to decreased CO. NPV improving ventilation and work of breathing in patients with chronic obstructive pulmonary disease (COPD).

Study Timeline

• Study Start: 2018-01-01
• Status Verified: 2019-11
• Study First Submitted: 2019-11-16
• Primary Completion: 2019-11-30
• Study First Submitted QC: 2019-12-25
• Study First Posted: 2019-12-27
• Study Completion: 2019-12-31
• Last Update Submitted: 2020-01-13
• Last Update Posted: 2020-01-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Patients with COPD who received pulmonary rehabilitation program with NPV treatment

Exclusion Criteria

• Recent exacerbation within 3-months
• Existing of tracheostomy
• Absence of NPV used
• Required of oxygen supplement during NPV
• Diagnosed of neuromuscular disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
NPV group	Received negative pressure ventilation	Patients who had treated in pulmonary rehabilitation unit with NPV

Primary Outcome Measures

Name	Time	Method
CO (cardiac output)	20 minutes	Change of Cardiac output before and after NPV treatment
SV (stroke volume)	20 minutes	Change of stroke volume before and after NPV treatment

Secondary Outcome Measures

Name	Time	Method
SpO2	20 minutes	Change of oxygen saturation before and after NPV treatment
RR (respiratory rate)	20 minutes	Change of respiratory rate before and after NPV treatment

Trial Locations

Locations (1)

Fu Jen Catholic University Hospital, Fu Jen Catholic University; 🇨🇳 New Taipei City, Taiwan