Strength Training Augmenting Rehabilitation - 1
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Muscle Disuse Atrophy
- Sponsor
- Texas Christian University
- Enrollment
- 20
- Locations
- 2
- Primary Endpoint
- Changes in muscle size
- Last Updated
- 4 years ago
Overview
Brief Summary
This project aims to determine whether a novel strength training rehabilitation protocol can diminish the negative consequences of limb immobilization and expedite the restoration of muscle function during retraining in healthy individuals.
Detailed Description
The present study will examine the time course of muscle strength and size adaptations in two groups of volunteers during immobilization and retraining. Both groups will undergo temporary muscle disuse by wearing a shoulder sling and swathe on their non-dominant arm for \~≥10 hours/day for four weeks. One group (immobilization + unilateral training) will perform progressive unilateral strength training of the free limb throughout the immobilization period. The other group (immobilization control) will not undergo any training during the immobilization period. Following immobilization, both groups will undergo four weeks of bilateral strength training to retrain the immobilized arm.
Investigators
Joshua Carr
Assistant Professor
Texas Christian University
Eligibility Criteria
Inclusion Criteria
- •a body mass index between 18 - 35 kg/m2
- •18-35 years of age
- •right-hand dominant
- •willingness to comply with the immobilization requirements
- •willingness to refrain from strength training outside of the study
- •willingness to comply with the strength training procedures of the study
Exclusion Criteria
- •a personal or family history of blood clots
- •a personal or family history of thyroid disorders
- •previous orthopedic surgeries to the upper limbs and/or joint pain of the upper limbs in the last 6 months
- •neuromuscular or metabolic disorders
- •osteoarthritis
- •use of hormone replacement therapy (ie., testosterone, estrogen, and/or growth hormone pharmaceuticals)
- •pregnancy and/or nursing
Outcomes
Primary Outcomes
Changes in muscle size
Time Frame: Changes from baseline at 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 weeks
Ultrasound muscle thickness of biceps brachii and triceps brachii
Changes in isometric muscle strength
Time Frame: Changes from baseline at 5 and 10 weeks
MVC (Newton)
Changes in dynamic muscle strength
Time Frame: Changes from baseline at 5 and 10 weeks
1RM (lbs)
Changes in lean mass
Time Frame: Changes from baseline at 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 weeks
DEXA
Changes in EMG amplitude
Time Frame: Changes from baseline at 5 and 10 weeks
Surface EMG
Changes in action potential amplitude
Time Frame: Changes from baseline at 5 and 10 weeks
Surface EMG Decomposition