To Compare the Analgesic Effects of Different Nerve Block Analgesia Methods in Thoracoscopic Surgery

Not Applicable

Recruiting

• Conditions: Postoperative Analgesia
• Interventions: Other: TPVB group; Other: ESPB group; Other: TPVB combined ESPB group; Other: ICNB group

• Registration Number: NCT06598852
• Lead Sponsor: The First Hospital of Qinhuangdao

Brief Summary

Comparison of analgesic effects of ultrasound-guided thoracic paravertebral block, erector spinae muscle block, thoracic paravertebral block combined with erector spinae muscle block, and intercostal nerve block in thoracoscopic surgery

Detailed Description

120 patients undergoing elective thoracoscopic surgery were randomly divided into ESPB group (E group, n=30), TPVB group (T group, n=30), ESPB combine with TPVB group (ET group, n=30), ICNB group (I group, n=30). Patients in ESPB group underwent erector spinal block under ultrasound after anesthesia induction; Patients in TPVB group received thoracic paravertebral nerve block after anesthesia induction; Patients in ESPB group combined with TPVB group received thoracic paravertebral nerve block combined with erectoralis muscle block after anesthesia induction; Patients in INB group received intraoperative intercostal nerve block by the operator. All groups of patients received postoperative controlled intravenous analgesia (PCIA). Visual analogue scale (VAS) was used to evaluate the degree of pain 1h (T1), 24h (T2) and 48h (T3) after surgery. The mean arterial pressure (MAP), heart rate at T1-T3 were recorded, as well as the number of effective analgesic pump compression, the amount of sufentanil and the number of relief analgesia within 48h after surgery. The occurrence of postoperative adverse reactions such as nausea, vomiting, dizziness, retention time of thoracic drainage tube, postoperative hospital stay and postoperative pulmonary complications (pneumonia, atelectasis, pleural effusion, respiratory failure, etc.) were recorded.

Study Timeline

• Status Verified: 2024-08
• Study First Submitted: 2024-09-12
• Study First Submitted QC: 2024-09-12
• Study Start: 2024-09-15
• Study First Posted: 2024-09-19
• Primary Completion: 2024-11-20
• Last Update Submitted: 2024-11-28
• Last Update Posted: 2024-12-02
• Study Completion: 2025-01-20

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• (1) American Society of Anesthesiologists (ASA) Grade I-II; (2) Age: 18-70 years old (3) double-hole thoracic surgery was performed; (4) Agree to participate in this study and sign the informed consent.

Exclusion Criteria

• (1) People who are allergic to anesthetics used in this study; (2) Patients with coagulation disorders (3) patients with severe heart disease, liver or renal insufficiency; (4) have a history of chronic pain or chronic opioid users (5) have a co-existing mental illness and are not fully capable of cooperating

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
TPVB group	TPVB group	Ultrasound-guided thoracic paravertebral nerve block was used for postoperative analgesia after thoracic surgery
ESPB group	ESPB group	Ultrasound-guided erector spinae muscle block was used for postoperative analgesia after thoracic surgery
TPVB combined ESPB group	TPVB combined ESPB group	Ultrasound-guided thoracic paravertebral nerve block combined with erector spinae muscle block was used for postoperative analgesia after thoracic surgery
ICNB group	ICNB group	Intercostal nerve block was used for postoperative analgesia after thoracic surgery

Primary Outcome Measures

Name	Time	Method
Postoperative pain score	48 hours after surgery	Visual analogue scale (VAS) was used to evaluate the degree of pain 1h (T1), 24h (T2) and 48h (T3) after surgery, the number of effective analgesic pump compressions and the number of remedial analgesia within 48h after surgery.

Secondary Outcome Measures

Name	Time	Method
Incidence of postoperative complications	48 hours after surgery	Mean arterial pressure (MAP), heart rate, postoperative nausea, vomiting, dizziness and other adverse reactions at T1-T3, retention time of thoracic drainage tube, and postoperative pulmonary complications (pneumonia, atractasis, pleural effusion, respiratory failure, etc.)

Trial Locations

Locations (1)

First hospital of Qinhuangdao; 🇨🇳 Qinhuangdao, Hebei, China