ISRCTN44343129已完成未知
Impact of neo-adjuvant chemotherapy on cardiorespiratory reserve in oesophago-gastric carcinoma
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 入组人数
- 31
研究概览
简要总结
2018 results in https://www.ncbi.nlm.nih.gov/pubmed/29601082 (added 24/01/2020)
研究设计
- 研究类型
- Observational
入排标准
- 性别
- All
入选标准
- •1. Histological diagnosis of adenocarcinoma of the oesophagus or stomach
- •2. Patients deemed suitable for neo-adjuvant chemotherapy prior to resectional surgery
- •3. Absolute or relative contraindication in the patient’s ability to perform serial (cardiopulmonary exercise tests) CPETs
- •4. Written informed consent
- •5. Aged 18 years and over
排除标准
- •1. A pathological diagnosis other than adenocarcinoma.
- •2. Inability to consent or withdrawal of consent at any point during the research process
- •3.Absolute or relative contraindication to CPET testing:
- •3.1. Absolute:
- •3.1.1. Acute myocardial infarction (3–5 days)
- •3.1.2. Unstable angina
- •3.1.3. Uncontrolled arrhythmias causing symptoms or haemodynamic compromise
- •3.1.4. Syncope
- •3.1.5. Active endocarditis
- •3.1.6. Acute myocarditis or pericarditis
- •3.1.7. Symptomatic severe aortic stenosis
- •3.1.8. Uncontrolled heart failure
- •3.1.9. Acute pulmonary embolus or pulmonary infarction
- •3.1.10. Thrombosis of lower extremities
- •3.1.11. Suspected dissecting aneurysm
- •3.1.12. Uncontrolled asthma
- •3.1.13. Pulmonary oedema
- •3.1.14. Room air desaturation at rest 85%*
- •3.1.15. Respiratory failure
- •3.1.16. Acute non-cardiopulmonary disorder that may affect exercise performance or be aggravated by exercise (ie, infection, renal failure, thyrotoxicosis)
- •3.1.17. Mental impairment leading to inability to cooperate
- •3.2. Relative:
- •3.2.1. Left main coronary stenosis or its equivalent
- •3.2.2. Moderate stenotic valvular heart disease
- •3.2.3. Severe untreated arterial hypertension at rest or haemodynamic compromise (>200 mm Hg systolic, >120 mm Hg diastolic)
- •3.2.4. Tachyarrhythmias or bradyarrhythmias
- •3.2.5. High-degree atrioventricular block
- •3.2.6. Hypertrophic cardiomyopathy
- •3.2.7. Significant pulmonary hypertension
- •3.2.8. Advanced or complicated pregnancy
- •3.2.9. Electrolyte abnormalities
- •3.2.10. Orthopaedic impairment that compromises exercise performance
研究者
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