sCTA combined with cerebrovascular segmentation technique to assess the compensatory status of collateral circulation in acute ischemic stroke and neurological function Correlation between neurological and cognitive function and complex pathology classificatio

Not Applicable

• Conditions: Acute ischemic stroke

• Registration Number: ITMCTR2200006470
• Lead Sponsor: SHENZHEN INSTITUTE OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCES

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

?meeting Western medical diagnostic criteria.
?Patients of any gender, aged between 18 and 80 years, whose mother tongue is Chinese.
?The patient has undergone an emergency CT and CTA scan to confirm the presence of at least one intracranial arterial stenosis (=50% stenosis) and that the responsible vessel is located in a unilateral middle cerebral artery M1 segment occlusion.
? Patients with an onset to presentation time of no more than 8 hours and who have been ascertained by CT plain scan to be free of intracranial haemorrhage or tumourous lesions or other disease before undergoing sCTA scanning.
?The patient has not had any clinical management within 8 hours of presentation and the clinician has scored the patient on the NIHSS for clinical presentation since admission.
? No dementia criteria attached, all with varying degrees of cognitive impairment and a Simple Mental Status Examination Scale (MMSE) score =20.
? No severe impairment of consciousness or even coma.
?Inform the patient and the patient's family of their consent and sign the relevant informed consent form.

Exclusion Criteria

?Patients whose age is not within the inclusion criteria; patients with an onset time of more than 8 hours.
?Patients with <50% stenosis of the vessel responsible for the lesion.
?Patients with a combination of other significant systemic or organ pathologies (e.g. serious pathologies of the heart, lungs, liver, kidneys, etc.) that are intolerant of CTA examination.
?Patients with non-atherosclerotic disease with high suspicion of arteritis, smog, cerebrovascular malformation or cardiogenic embolism.
? Patients who are pregnant or breastfeeding or who are allergic to contrast agents and should not undergo CTA.
?Patients with agitation, disorders of consciousness, aphasia, visual and hearing impairment and psychiatric disorders who are unable to cooperate with CTA examination and follow-up.
?Patients with other causes of cognitive impairment, including congenital mental retardation, history of brain surgery, occupational lesions, metabolic encephalopathy, family history, etc.
?Neurological deficits due to cerebral haemorrhage, central nervous system infection, epilepsy, aura migraine or other diseases.
?Involuntary participation in this study and refusal by the patient or the patient's family to sign the relevant informed consent form.

Study & Design

• Study Type: Observational study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Montreal Cognitive Assessment;Dialectical Typing in Chinese Medicine;rLMC score;National Institute of Health stroke scale;