Assessment of Cerebrovascular Function in Patients with previous Aortic Coarctation Repair
Not Applicable
Completed
- Conditions
- Aortic Coarctation - congenital heart diseaseCardiovascular - Other cardiovascular diseases
- Registration Number
- ACTRN12615000418572
- Lead Sponsor
- John Hunter Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Adult patients having undergone previous surgical repair of aortic coarctation in childhood, having measurable ultrasound signal on both sides of the head. Control participants should be healthy and without heart disease.
Exclusion Criteria
Unable to obtain a measurable signal in both left and right MCA.
History of cerebrovascular events including transient ischemic attack.
Uncontrolled hypertension (>160/100mmHg) (measured at the visit to CNRC).
Smokers or those currently on nicotine therapy.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br> Cerebrovascular responsiveness (CVR) to hypercapnia at the level of the middle cerebral artery (MCA).<br><br> Increases in blood flow velocity in the MCA. Basal cerebral blood flow velocities for 10 cardiac cycles will first be recorded to determine the blood flow velocity (peak systolic, end diastolic and mean) at rest. The measures of cerebral pulsatility and resistive indexes will also be recorded simultaneously. During CVR to hypercapnia, participants breathe carbogen (5% CO2, 95% O2) for 150 seconds and the peak increase of blood flow velocity is recorded. This procedure is done in triplicates with a resting interval of at least 2min between each recording. [Week 1, one visit only.]<br>
- Secondary Outcome Measures
Name Time Method