Intravenous Dexamethasone Combined With Intrathecal Atropine to Prevent Morphine-related Nausea and Vomiting After Cesarean Delivery: A Randomized Double-blinded Study
Overview
- Phase
- Not Applicable
- Intervention
- Intrathecal atropine
- Conditions
- Postoperative Nausea
- Sponsor
- Assiut University
- Enrollment
- 120
- Locations
- 1
- Primary Endpoint
- postoperative nausea
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
optimal postoperative pain control with intrathecal morphine, with proper prevention of postoperative nausea and vomiting. Dexamethasone, and or atropine could offer some protection against nausea and vomiting.
Detailed Description
One of the gold standards for analgesia following cesarean delivery is intrathecal morphine, which is not devoid of complications namely postoperative nausea and vomiting. We evaluated the antiemetic effect of intravenous dexamethasone combined with intrathecal atropine after cesarean delivery under spinal bupivacaine plus morphine anesthesia.
Investigators
Emad Zarief , MD
Dr
Assiut University
Eligibility Criteria
Inclusion Criteria
- •18-40 years of age
- •elective cesarean delivery under bupivacaine spinal anesthesia
Exclusion Criteria
- •renal disease
- •preeclampsia
- •liver disease
- •cardiac disease
- •Coagulopathy
- •chronic cough
- •patient refusal
Arms & Interventions
Atropine group
Atropine group (A): Patients received intrathecal heavy Marcaine, 2 ml, 0.5% plus 300 µg morphine and 100 µg atropine (0.5ml), and intravenous injection of 2ml normal saline.
Intervention: Intrathecal atropine
Dexamethasone group
Dexamethasone group (D): Patients received intrathecal heavy Marcaine 2 ml, 0.5% plus 300 µg morphine (0.5ml), and intravenous 8 mg dexamethasone (2ml).
Intervention: dexamethasone
Dexamethasone and Atropine group
Dexamethasone and Atropine group (DA): Patients received intrathecally as group A, plus intravenous injection of 2 ml, dexamethasone 8 mg. Postoperative follow-up of both nausea and vomiting was done over 24 hours postoperative.
Intervention: Intrathecal atropine
Dexamethasone and Atropine group
Dexamethasone and Atropine group (DA): Patients received intrathecally as group A, plus intravenous injection of 2 ml, dexamethasone 8 mg. Postoperative follow-up of both nausea and vomiting was done over 24 hours postoperative.
Intervention: dexamethasone
Outcomes
Primary Outcomes
postoperative nausea
Time Frame: 24 hours
Monitoring scale of nausea and vomiting