Intrathecal Atropine to Prevent Postoperative Nausea and Vomiting

Not Applicable

Completed

• Conditions: Postoperative Nausea
• Interventions: Drug: Intrathecal atropine; Drug: dexamethasone

• Registration Number: NCT03387956
• Lead Sponsor: Assiut University

Brief Summary

optimal postoperative pain control with intrathecal morphine, with proper prevention of postoperative nausea and vomiting. Dexamethasone, and or atropine could offer some protection against nausea and vomiting.

Detailed Description

One of the gold standards for analgesia following cesarean delivery is intrathecal morphine, which is not devoid of complications namely postoperative nausea and vomiting. We evaluated the antiemetic effect of intravenous dexamethasone combined with intrathecal atropine after cesarean delivery under spinal bupivacaine plus morphine anesthesia.

Study Timeline

• Study Start: 2017-03-20
• Primary Completion: 2017-07-28
• Study Completion: 2017-08-10
• Study First Submitted: 2017-12-20
• Study First Submitted QC: 2017-12-24
• Study First Posted: 2018-01-02
• Status Verified: 2018-06
• Last Update Submitted: 2018-06-04
• Last Update Posted: 2018-06-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 120

Inclusion Criteria

• females
• 18-40 years of age
• elective cesarean delivery under bupivacaine spinal anesthesia

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Exclusion Criteria

• renal disease
• preeclampsia
• liver disease
• cardiac disease
• Coagulopathy
• chronic cough
• nausea
• vomiting
• patient refusal

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Atropine group	Intrathecal atropine	Atropine group (A): Patients received intrathecal heavy Marcaine, 2 ml, 0.5% plus 300 µg morphine and 100 µg atropine (0.5ml), and intravenous injection of 2ml normal saline.
Dexamethasone and Atropine group	Intrathecal atropine	Dexamethasone and Atropine group (DA): Patients received intrathecally as group A, plus intravenous injection of 2 ml, dexamethasone 8 mg. Postoperative follow-up of both nausea and vomiting was done over 24 hours postoperative.
Dexamethasone and Atropine group	dexamethasone	Dexamethasone and Atropine group (DA): Patients received intrathecally as group A, plus intravenous injection of 2 ml, dexamethasone 8 mg. Postoperative follow-up of both nausea and vomiting was done over 24 hours postoperative.
Dexamethasone group	dexamethasone	Dexamethasone group (D): Patients received intrathecal heavy Marcaine 2 ml, 0.5% plus 300 µg morphine (0.5ml), and intravenous 8 mg dexamethasone (2ml).

Primary Outcome Measures

Name	Time	Method
postoperative nausea	24 hours	Monitoring scale of nausea and vomiting

Trial Locations

Locations (1)

Emad Zarief Kamel Said; 🇪🇬 Assiut, Egypt