Intrathecal Atropine to Prevent Postoperative Nausea and Vomiting
Not Applicable
Completed
- Conditions
- Postoperative Nausea
- Interventions
- Registration Number
- NCT03387956
- Lead Sponsor
- Assiut University
- Brief Summary
optimal postoperative pain control with intrathecal morphine, with proper prevention of postoperative nausea and vomiting. Dexamethasone, and or atropine could offer some protection against nausea and vomiting.
- Detailed Description
One of the gold standards for analgesia following cesarean delivery is intrathecal morphine, which is not devoid of complications namely postoperative nausea and vomiting. We evaluated the antiemetic effect of intravenous dexamethasone combined with intrathecal atropine after cesarean delivery under spinal bupivacaine plus morphine anesthesia.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 120
Inclusion Criteria
- females
- 18-40 years of age
- elective cesarean delivery under bupivacaine spinal anesthesia
Exclusion Criteria
- renal disease
- preeclampsia
- liver disease
- cardiac disease
- Coagulopathy
- chronic cough
- nausea
- vomiting
- patient refusal
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Atropine group Intrathecal atropine Atropine group (A): Patients received intrathecal heavy Marcaine, 2 ml, 0.5% plus 300 µg morphine and 100 µg atropine (0.5ml), and intravenous injection of 2ml normal saline. Dexamethasone and Atropine group Intrathecal atropine Dexamethasone and Atropine group (DA): Patients received intrathecally as group A, plus intravenous injection of 2 ml, dexamethasone 8 mg. Postoperative follow-up of both nausea and vomiting was done over 24 hours postoperative. Dexamethasone and Atropine group dexamethasone Dexamethasone and Atropine group (DA): Patients received intrathecally as group A, plus intravenous injection of 2 ml, dexamethasone 8 mg. Postoperative follow-up of both nausea and vomiting was done over 24 hours postoperative. Dexamethasone group dexamethasone Dexamethasone group (D): Patients received intrathecal heavy Marcaine 2 ml, 0.5% plus 300 µg morphine (0.5ml), and intravenous 8 mg dexamethasone (2ml).
- Primary Outcome Measures
Name Time Method postoperative nausea 24 hours Monitoring scale of nausea and vomiting
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Emad Zarief Kamel Said
🇪🇬Assiut, Egypt
Emad Zarief Kamel Said🇪🇬Assiut, Egypt