Meibomian Gland Dysfunction (MGD) and Tear Cytokines After Cataract Surgery According to Preoperative Meibomian Gland Status

Completed

• Conditions: Cataract

• Registration Number: NCT02411487
• Lead Sponsor: Yonsei University

Brief Summary

To investigate the possible mechanisms by which cataract surgery aggravates meibomian gland dysfunction (MGD), the investigators evaluated the changes in tear cytokines and ocular surface parameters after cataract surgery according to the preoperative MGD grade.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2015-03-05
• Study Start: 2015-03-16
• Study First Submitted QC: 2015-04-02
• Study First Posted: 2015-04-08
• Primary Completion: 2015-08-03
• Study Completion: 2015-08-03
• Status Verified: 2017-01
• Last Update Submitted: 2017-01-23
• Last Update Posted: 2017-01-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• males or non-pregnant females aged between 55 to 80 years-old.

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Exclusion Criteria

• had a history of ocular diseases, such as ocular infection, ocular allergy, and autoimmune disease, as well as patients with continuous use of topical ocular medications before surgery, or histories of ocular surgery or ocular injury.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
inflammatory tear cytokine concentration	1 month after cataract surgery	comparison of tear cytokines (IL-2,4,10,17a, INF-r, TNF-a) concentrations in patients with or without newly diagnosed chronic GVHD after SCT using a multiplex immunobead assay
ocular surface staining	1 month after cataract surgery
tear film break-up time,	1 month after cataract surgery
conjunctival injection,	1 month after cataract surgery
Schirmer's test I	1 month after cataract surgery
ocular surface disease index	1 month after cataract surgery

Trial Locations

Locations (1)

Department of Ophthalmology; 🇰🇷 Seoul, Korea, Republic of