utrition and the neural development of spatial cognition using fMRI
Withdrawn
- Conditions
- geen van bovenstaande (gezonde proefpersonen)not applicable
- Registration Number
- NL-OMON45717
- Lead Sponsor
- Radboud Universiteit Nijmegen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 55
Inclusion Criteria
Age: 8-10
Healthy
fMRI compatible
Proficient use of Dutch in both child and parent
Exclusion Criteria
- Deafness, blindness, or sensori-motor handicaps
- Neuropsychiatric disorders
- Diabetes
- Chronic inflammatory diseases
- Daily use of ibuprofen, aspirin or glucocorticoids
- Any recent tooth extraction one month prior to the experiment
- History of oral candidiasis
- Acute illness with fever, vomiting, or diarrhea within 5 days of the study
- Recent use of antibiotics (within 3 months prior to the experiment);Exclusion criteria for MRI:
- Non-removable metal in the upper body
- Active implant, pacemaker, neurostimulator, insulin pump and/or auditory prosthetic
- Epilepsy
- Claustrophobia
- Brain surgery in the anamnesis
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Brain activation patterns (fMRI) pre and post training are the main outcome<br /><br>measures for this study. These will be related to nutrition and performance. In<br /><br>addition, we will assess the degree to which the aforementioned relationship is<br /><br>mediated by inflammation.</p><br>
- Secondary Outcome Measures
Name Time Method <p>The mediating effect of DNA methylation on the relation between nutrition and<br /><br>the brain activation patterns will also be assessed.</p><br>