Effects of small intestinal L-glutamate and L-glutamine infusions on antropyloroduodenal motility, gut hormone release, blood glucose control and energy intake in healthy, normal weight subjects.

Christine Feinle-Bisset0 个研究点目标入组 20 人开始时间: 2012年8月6日最近更新: 2020年1月13日

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•A total of 20 Caucasian male and female (BMI 18-25 kg/m2) subjects, aged between 18 - 50 years, will be included in the study. All subjects will be required to be weight-stable (i.e. less than 5 % fluctuation in their body weight) at study entry, as determined by their self-reported weight in the preceding 3 months, and will be required to maintain their normal physical activity over the course of the study.

•Significant gastrointestinal symptoms, disease or surgery, use of prescribed or non-prescribed medications (including vitamins and herbal supplements) which may affect energy metabolism, gastrointestinal function, body weight or appetite (eg domperidone and cisapride, anticholinergic drugs (eg atropine), metoclopramide, erythromycin, hyoscine, orlistat, green tea extracts, Astragalus, St Johns Wort etc.)
•lactose intolerance/ MSG intolerance/other food allergy(ies), current gallbladder or pancreatic disease, diabetes mellitus, as defined by fasting glucose greater than 6.9 mmol/l and/or glycated haemoglobin equal to 6.2 %, cardiovascular or respiratory diseases, individuals with low ferritin levels (females less than 15 ng/mL, males less than 30 ng/mL), or who have donated blood in the 12 weeks prior to taking part in the study, any other illnesses as assessed by the investigator (including chronic illnesses not explicitly listed above), high performance athletes, current intake of greater than 2 standard drinks on greater than 5 days per week, current smokers of cigarettes/cigars/marijuana, current intake of any illicit substance, vegetarians. In female subjects, pregnancy or lactation.

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