Effect of Physical Inactivity on Endothelial Function
Overview
- Phase
- Phase 1
- Intervention
- salsalate
- Conditions
- Insulin Resistance
- Sponsor
- Boston University
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Reactive hyperemia in the femoral artery
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
Physical inactivity induces vascular dysfunction and glucose intolerance during five days of bed rest. This study will investigate the effects of salsalate on these responses. Subjects will be randomized to treatment with salsalate or placebo for four days prior to initiation of bed rest. Vascular function in the brachial artery will be determined by ultrasound prior to treatment and before and after the 5-day bed rest protocol. We hypothesize that treatment with salsalate will be associated with protection again the development of glucose intolerance and vascular dysfunction in this setting.
Investigators
Naomi M Hamburg
Principal Investigator
Boston University
Eligibility Criteria
Inclusion Criteria
- •Healthy volunteers
Exclusion Criteria
- •Pregnancy
- •History of Coronary Artery Disease
- •Diabetes Mellitus
- •Hypertension
- •Cigarette smoking
- •History or family history of deep vein thrombosis or pulmonary embolism
- •Abnormal renal function
- •Liver function tests greater than two times the upper limit of normal
- •Use of viagra or other PDE5 inhibitor
- •Hypercholesterolemia
Arms & Interventions
Salsalate
Salsalate
Intervention: salsalate
Placebo
Placebo
Intervention: Placebo
Outcomes
Primary Outcomes
Reactive hyperemia in the femoral artery
Time Frame: 5 days
Secondary Outcomes
- Reactive hyperemia in the brachial artery(5 days)
- Oral glucose tolerance test(5 days)