Vascular Dysfunction During Physical Inactivity: Role of Oxidative Stress
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Aging
- Sponsor
- University of Utah
- Enrollment
- 14
- Locations
- 1
- Primary Endpoint
- Brachial Artery Vascular Function
- Status
- Completed
- Last Updated
- 3 months ago
Overview
Brief Summary
Prolonged periods of reduced activity are associated with decreased vascular function and muscle atrophy. Physical inactivity due to a sedentary lifestyle or acute hospitalization is also associated with impaired recovery, hospital readmission, and increased mortality. Older adults are a particularly vulnerable population as functional (vascular and skeletal muscle mitochondrial dysfunction) and structural deficits (loss in muscle mass leading to a reduction in strength) are a consequence of the aging process. The combination of inactivity and aging poses an added health threat to these individuals by accelerating the negative impact on vascular and skeletal muscle function and dysfunction. The underlying factors leading to vascular and skeletal muscle dysfunction are unknown, but have been linked to increases in oxidative stress. Additionally, there is a lack of understanding of how vascular function is impacted by inactivity in humans and how these changes are related to skeletal muscle function. It is the goal of this study to investigate the mechanisms that contribute to disuse muscle atrophy and vascular dysfunction in order to diminish their negative impact, and preserve vascular and skeletal muscle function.
Investigators
Joel Trinity
Associate Professor
University of Utah
Eligibility Criteria
Inclusion Criteria
- •Individuals who have recently undergone surgery or injury requiring inactivity
Exclusion Criteria
- •Cardiac abnormalities considered exclusionary by the study physician (congestive heart failure, coronary artery disease, right-to-left shunt)
- •Uncontrolled endocrine or metabolic disease
- •Glomerular filtration rate \< 45 mL/min/1.73 m\^2 or evidence of kidney disease or failure
- •Vascular disease or risk factors of peripheral atherosclerosis
- •Risk of deep vein thrombosis including family history of thrombophilia, pulmonary emboli, deep vein thrombosis
- •Use of anticoagulant therapy
- •Elevated systolic pressure \> 180 or a diastolic blood pressure \> 110
- •Implanted electronic devices such as pacemakers, infusion pumps, stimulators
- •Cancer or history of successfully treated cancer (less than 1 year) other than basal cell carcinoma
- •Currently on a weight-loss diet or body mass index \> 35 kg/m\^2
Outcomes
Primary Outcomes
Brachial Artery Vascular Function
Time Frame: Baseline, during reduced activity (2 weeks) and 2 weeks post reduced activity (4 weeks)
The flow rate of brachial artery measured by flow-mediated dilation (FDM). Doppler ultrasound will be used to determine brachial artery vascular function. Specifically, this assessment will include the measurement of flow rate and artery diameter at rest and in response to flow mediated dilation.
Secondary Outcomes
- Popliteal Artery Vascular Function(Baseline, during reduced activity (2 weeks) and 2 weeks post reduced activity (4 weeks))
- Leg Microvascular Function(Baseline, during reduced activity (2 weeks) and 2 weeks post reduced activity (4 weeks))