Effect of Fentanyl on Coughing and Recovery After Anesthesia With an LMA Laryngeal Mask Airway)for Airway Management
- Registration Number
- NCT01368809
- Lead Sponsor
- Cedars-Sinai Medical Center
- Brief Summary
The purpose of this research is to evaluate the effectiveness of fentanyl for reducing coughing during the perioperative period (i.e., insertion of an LMA \[Laryngeal Mask Airway\] device, maintenance period during surgery, and awakening \[emergence\] from general anesthesia) for ambulatory surgery procedures. Also to assess the effects of fentanyl on the postoperative outcomes, (e.g., pain, postoperative nausea and vomiting, return of bowel function \[constipation\], resumption of normal activities of daily living).
Fentanyl is one of the most common used anesthetic adjuncts for ambulatory surgery because of its anesthetic-sparing effects and alleged ability to reduce coughing during instrumentation of the patient's airway.
- Detailed Description
This research study is designed to evaluate the effects of fentanyl when administered as an adjuvant to standard anesthetic and analgesic drugs on coughing (during insertion of an LMA device, during maintenance and emergence from general anesthesia) and on the postoperative adverse outcomes (i.e., side effects).
All patients will receive local anesthetics and commonly used non-opioid pain relieving medications during surgery.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Fentanyl Fentanyl Fentanyl (50 µg/ml) 2 ml at induction, 1-2 ml boluses as needed Saline Solution Saline Saline Solution 2 ml at induction, 1-2 ml boluses as needed
- Primary Outcome Measures
Name Time Method Incidence of Coughing one day during the perioperative period (insertion of an LMA device, maintenance of anesthesia, and emergence from general anesthesia) for ambulatory surgery procedures.
- Secondary Outcome Measures
Name Time Method Postoperative Pain one day Postoperative pain measured using a Verbal Rating Scale (VRS) at post-anesthesia care unit (PACU), (90 minutes after arriving).
Postoperative pain VRS scores: 0 = none pain to 10 = intolerable pain.Incidence of Nausea and Vomiting 1 day Postoperative nausea and vomiting using a Verbal Rating Scale (0-10) at PACU (post-anesthesia care unit.
Trial Locations
- Locations (1)
Cedars Sinai Medical center
🇺🇸Los Angeles, California, United States