Study on Correlation Between Vascular ET-1 and Adiponectin in Pediatric Obesity

• Conditions: OBESITY; Endothelial Dysfunction; Insulin Resistance

• Registration Number: NCT01750333
• Lead Sponsor: Monica Montagnani

Brief Summary

The aim of this study is to explore whether and how high circulating levels of endothelin-1 (ET-1) in obese and overweight children may contribute to impair adiponectin (Ad) production, release and vascular activity

Detailed Description

Not available

Study Timeline

• Study Start: 2012-04
• Status Verified: 2012-12
• Study First Submitted: 2012-12-12
• Study First Submitted QC: 2012-12-12
• Last Update Submitted: 2012-12-12
• Study First Posted: 2012-12-17
• Last Update Posted: 2012-12-17
• Primary Completion: 2013-03
• Study Completion: 2013-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Children will be enrolled into lean, overweight or obese groups based on Body mass index (BMI) calculated according to standard methods. International standards for sex-and age-specific BMI centiles for subjects aged 2-18 years will be used. The 95th centile of BMI reference is the cut off point for childhood obesity. Overweight and obese children are defined as those with a BMI higher than the centile curves.

Exclusion Criteria

• presence of renal, liver and/or cardiovascular diseases;
• hypertension;
• metabolic and/or endocrine disorders;
• genetic syndromes;
• histories of chronic allergies, acute infectious or inflammatory diseases during the last 3 months preceding the study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation between serum levels of ET-1 and Ad in lean, overweight and obese children	12 months

Trial Locations

Locations (1)

University of Bari Medical School - Dept Biomedical Sciences and Human Oncology; 🇮🇹 Bari, Italy