FLUID MANAGEMENT TARGETED ON DIFFERENT VARIABLES OF PERIPHERAL PERFUSION IN PATIENTS ADMITTED TO THE INTENSIVE CARE UNIT.
Completed
- Conditions
- Peripheral perfusion, fluid management, critically ill patients, intensive care unit.Perifere perfusie, vochttoediening, kritisch zieke patienten, intensive care.
- Registration Number
- NL-OMON20877
- Lead Sponsor
- Erasmus Medical Centre
- Brief Summary
1. The relation of near-infrared spectroscopy with changes in peripheral circulation in critically ill patients;<br> 2. The prognostic value of the subjective assessment of peripheral perfusion in critically ill patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
All adult (age > 18 years) patients admitted to the Intensive Care Unit with:
1. Hemodynamic instability due to severe sepsis;
Exclusion Criteria
1. Moribund;
2. Severe coagulation disorder (contraindication for central venous catheter placement);
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Daily fluid balance;<br /><br>2. Total fluid balance over Intensive Care Unit admission period.
- Secondary Outcome Measures
Name Time Method 1. Parameters of peripheral perfusion:<br /><br>A. Capillary refill time;<br /><br>B. Peripheral flow index;<br /><br>C. Forearm skin temperature difference;<br /><br>D. Tissue oxygen saturation.<br /><br>2. Systemic hemodynamic parameters:<br /><br>A. Mean arterial blood pressure;<br /><br>B. Central venous pressure;<br /><br>C. Central venous hemoglobin oxygen saturation;<br /><br>D. Cardiac output and stroke volume.<br /><br>3. Respiratory function: <br /><br>A. Arterial oxygen pressure/inspired oxygen fraction ratio (PaO2/FiO2 ratio);<br /><br>B. Duration of mechanical ventilation.