Characterization and Differential Diagnosis of Vertebral Osteomyelitis
- Conditions
- Vertebral Osteomyelitis
- Registration Number
- NCT01125839
- Lead Sponsor
- Asan Medical Center
- Brief Summary
Vertebral osteomyelitis is a uncommon disease that can lead to neurologic deficits if not diagnosed in time. The etiologies of vertebral osteomyelitis include pyogenic bacteria, M. tuberculosis, Brucella species, and fungus. The aim of this study is to describe the clinical features and microbiological/radiological characteristics of patients with vertebral osteomyelitis, and investigate the useful tips for the differential diagnosis of vertebral osteomyelitis.
- Detailed Description
Besides description of characteristics of patients with vertebral osteomyelitis, we also will investigate the usefulness of 16S rRNA gene sequence analysis of biopsy specimen. MRI findings during the antibiotic treatment will be monitored and compared for the differential diagnosis of meningitis.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 100
- Symptoms or signs consistent with spinal column infection
- MRI findings suggestive of infection
- Antibiotic treatment for vertebral myelitis
- Patients already treated more than 2 weeks for osteomyelitis in transferring hospital
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Identification of etiology of vertebral osteomyelitis within 6 weeks after the diagnosis of vertebral osteomyelitis
- Secondary Outcome Measures
Name Time Method Unfavorable outcomes (death or permanent neurologic deficit) within 6 months after the diagnosis of vertebral osteomyelitis
Trial Locations
- Locations (1)
Asan Medical Center
🇰🇷Seoul, Korea, Republic of