Efficacy of Cognitive Training in Subjective Memory Impairment

Not Applicable

Completed

• Conditions: Memory Loss
• Interventions: Behavioral: cognitive training; Behavioral: lifestyle modification

• Registration Number: NCT02555774
• Lead Sponsor: Asan Medical Center

Brief Summary

This study evaluates the efficacy of cognitive training in subjects with subjective memory impairment. The first group will receive cognitive training and lifestyle modification in combination, the second group will receive only lifestyle modification, and the third group will receive no intervention.

Detailed Description

Subjective memory impairment is currently thought to be a risky state of progression to Alzheimer's disease. This study aims to confirm whether cognitive training in subjective memory impairment would show improvement in the subjective and objective cognition. We include subjects with normal cognition but complained subjective feeling of memory decline and conduct cognitive training programs combined with lifestyle modifications for 3 months. We evaluate the neuropsychological tests and questionnaires about subjective improvement after 3 months of interventions.

Study Timeline

• Study Start: 2014-05
• Study First Submitted: 2015-09-18
• Study First Submitted QC: 2015-09-21
• Study First Posted: 2015-09-22
• Primary Completion: 2015-11
• Study Completion: 2016-02
• Status Verified: 2018-08
• Last Update Submitted: 2018-08-06
• Last Update Posted: 2018-08-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 65

Inclusion Criteria

• Subjects who showed normal range (above 16percentile of norm) in all domains of detailed neuropsychological tests battery named Seoul Neuropsychological Screening Battery (SNSB)
• Clinical dementia rating (CDR) score of 0
• Subjects with at least 3 years of formal education

Read More

Exclusion Criteria

• Subjects with mild cognitive impairment or dementia
• Subjects who was diagnosed as any neurological disorders such as epilepsy, stroke, hemorrhage, hydrocephalus, Parkinson's disease or brain tumor
• Subjects with uncontrolled severe medical conditions according to investigator's opinion

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
cognitive training	cognitive training	Cognitive training programs 2 times a week for 3 months (totally 24 sessions) for 90 minutes per session. Lifestyle modification is educated first, then weekly phone call for lifestyle modification is done by investigators.
cognitive training	lifestyle modification	Cognitive training programs 2 times a week for 3 months (totally 24 sessions) for 90 minutes per session. Lifestyle modification is educated first, then weekly phone call for lifestyle modification is done by investigators.
lifestyle modification	lifestyle modification	This group receives only lifestyle modification for 3 months. Lifestyle modification is educated at the first, then weekly phone call for lifestyle modification is done by investigators. The method of lifestyle modification is same with the first arm.

Primary Outcome Measures

Name	Time	Method
Pattern recognition memory test	3 month	paired associates learning test is a part of computerized neuropsychological tests battery named CANTAB (Cambridge Neuropsychological Test Automated Battery). The score is shown as correct response rate.%
Spatial working memory test	3 month	paired associates learning test is a part of computerized neuropsychological tests battery named CANTAB (Cambridge Neuropsychological Test Automated Battery). The scores are shown as total number of errors.
Paired associates learning test	3 month	paired associates learning test is a part of computerized neuropsychological tests battery named CANTAB (Cambridge Neuropsychological Test Automated Battery). The scores are shown as total number of errors.
Rapid visual information processing test	3 month	rapid visual information processing is a part of computerized neuropsychological test battery named CANTAB. The score is shown as correct response rate.%

Secondary Outcome Measures

Name	Time	Method
cognitive failure questionnaire	3 month	questionnaire for measuring self reported cognitive status. score range: 0-100. Higher score means worse cognitive status.
Beck anxiety index	3 month	questionnaire for self reporting anxiety measuring. range:0-63. low score means less anxiety.
Seoul instrumental activities of daily living	3 month	scale for measuring activities of daily living limitation. score range 0-45. low score means better ability.
Rey complex figure copy test	3 month	test for visuospatial function. Participants should copy the complex figure. score range: 0-36. Higher score means better visuospatial function.
Mini-mental state examination	3 month	mini-mental state examination that examines general cognition. range 0-20. Higher score means better cognition.
Seoul verbal learning test, delayed recall	3 month	measuring tool for cued recall of verbal memory function. score range: 0-24. 2. Higher score means better memory recognition function
Logical memory test, delayed recall	3 month	logical memory test is a part of a neuropsychological test named Wechsler
Seoul verbal learning test, immediate recall	3 month	measuring tool for immediate memory function. Investigators read 12 words to participants. Participants should remember the words. Tests are done 3 times. score range: 0-36. Higher score means better immediate memory function
Geriatric depression scale	3 month	questionnaire for depression measuring. score range:0-15. lower score means less depression.
Digit symbol test	3 month	a test for attention and psychomotor speed. Participants are instructed to write an appropriately matched code for each number. Correct number is counted. score range: 0-76. Higher score means better function.

Trial Locations

Locations (1)

Jae-Hong Lee; 🇰🇷 Seoul, Korea, Republic of