Efficacy of Cognitive Training in Subjective Memory Impairment
- Conditions
- Memory Loss
- Registration Number
- NCT02555774
- Lead Sponsor
- Asan Medical Center
- Brief Summary
This study evaluates the efficacy of cognitive training in subjects with subjective memory impairment. The first group will receive cognitive training and lifestyle modification in combination, the second group will receive only lifestyle modification, and the third group will receive no intervention.
- Detailed Description
Subjective memory impairment is currently thought to be a risky state of progression to Alzheimer's disease. This study aims to confirm whether cognitive training in subjective memory impairment would show improvement in the subjective and objective cognition. We include subjects with normal cognition but complained subjective feeling of memory decline and conduct cognitive training programs combined with lifestyle modifications for 3 months. We evaluate the neuropsychological tests and questionnaires about subjective improvement after 3 months of interventions.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 65
- Subjects who showed normal range (above 16percentile of norm) in all domains of detailed neuropsychological tests battery named Seoul Neuropsychological Screening Battery (SNSB)
- Clinical dementia rating (CDR) score of 0
- Subjects with at least 3 years of formal education
- Subjects with mild cognitive impairment or dementia
- Subjects who was diagnosed as any neurological disorders such as epilepsy, stroke, hemorrhage, hydrocephalus, Parkinson's disease or brain tumor
- Subjects with uncontrolled severe medical conditions according to investigator's opinion
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Pattern recognition memory test 3 month paired associates learning test is a part of computerized neuropsychological tests battery named CANTAB (Cambridge Neuropsychological Test Automated Battery). The score is shown as correct response rate.%
Spatial working memory test 3 month paired associates learning test is a part of computerized neuropsychological tests battery named CANTAB (Cambridge Neuropsychological Test Automated Battery). The scores are shown as total number of errors.
Paired associates learning test 3 month paired associates learning test is a part of computerized neuropsychological tests battery named CANTAB (Cambridge Neuropsychological Test Automated Battery). The scores are shown as total number of errors.
Rapid visual information processing test 3 month rapid visual information processing is a part of computerized neuropsychological test battery named CANTAB. The score is shown as correct response rate.%
- Secondary Outcome Measures
Name Time Method cognitive failure questionnaire 3 month questionnaire for measuring self reported cognitive status. score range: 0-100. Higher score means worse cognitive status.
Beck anxiety index 3 month questionnaire for self reporting anxiety measuring. range:0-63. low score means less anxiety.
Seoul instrumental activities of daily living 3 month scale for measuring activities of daily living limitation. score range 0-45. low score means better ability.
Rey complex figure copy test 3 month test for visuospatial function. Participants should copy the complex figure. score range: 0-36. Higher score means better visuospatial function.
Logical memory test, delayed recall 3 month logical memory test is a part of a neuropsychological test named Wechsler
Seoul verbal learning test, immediate recall 3 month measuring tool for immediate memory function. Investigators read 12 words to participants. Participants should remember the words. Tests are done 3 times. score range: 0-36. Higher score means better immediate memory function
Digit symbol test 3 month a test for attention and psychomotor speed. Participants are instructed to write an appropriately matched code for each number. Correct number is counted. score range: 0-76. Higher score means better function.
Mini-mental state examination 3 month mini-mental state examination that examines general cognition. range 0-20. Higher score means better cognition.
Seoul verbal learning test, delayed recall 3 month measuring tool for cued recall of verbal memory function. score range: 0-24. 2. Higher score means better memory recognition function
Geriatric depression scale 3 month questionnaire for depression measuring. score range:0-15. lower score means less depression.
Related Research Topics
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Trial Locations
- Locations (1)
Jae-Hong Lee
🇰🇷Seoul, Korea, Republic of
Jae-Hong Lee🇰🇷Seoul, Korea, Republic of