Comparison of Pantoprazole and Ranitidine for preventing pulmonary infection in IC

Phase 2

Conditions: Condition 1: Pneumonia. Condition 2: GI bleeding.
Bacterial pneumonia, not elsewhere classified
K92.2 is a billable ICD-10-CM code that can be used to specify a diagnosis.

Registration Number: IRCT2013072014079N1

Lead Sponsor: Vice chancellor for research, Shiraz University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 166

Inclusion Criteria

Inclusion Criteria:
1. 18 Years of age and over
2. Intubation for more than 48 hours
3. No history of pneumonia within 3 months prior to or at the time of admission
4. No history of severe dysphagia
5. No history of deficiency in the immune system
6. No history of gastrointestinal bleeding
7. No history of gastrectomy, erosive gastritis, and reflux
8. No history of lung cancer
9. No transferring of patients from other ICUs.

Exclusion Criteria

1. Renal failure
2. Drug interference
3. Incidence of drug side effects
4. Gastrointestinal bleeding.

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Ventilator Associated Pneumonia. Timepoint: Daily until the sputum is positively cultured or 48 hours after extubation. Method of measurement: Clinical Pulmonary Infection Score (CPIS)- Sputum Culture.

Secondary Outcome Measures

Name	Time	Method
GI bleeding. Timepoint: Daily until the patient remains hospitalized. Method of measurement: Observing the coffee grain contents in the naso- or oro-gastric tube and Melena; checking vital signs such as blood pressure and heart rate, and hemoglobin.;Length of stay in ICU. Timepoint: At the end. Method of measurement: Observation.;Mortality in ICU. Timepoint: At the end. Method of measurement: Observation.;Mortality in ward. Timepoint: At the end. Method of measurement: Observation.;Duration of Mechanical Ventilation. Timepoint: Since the start of mechanical ventilation until the patient is disconnected from the machine. Method of measurement: Observation.