FDG-PET CT scan: an additional tool in detection of peripheral arterial disease and its compensatory capacities in patients with diabetes type 2, an observational pilot study.
- Conditions
- atheroslerosisperipheral arterial disease10003216
- Registration Number
- NL-OMON33453
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 14
Inclusion Criteria
type 2 diabetes,
presence of an threatened distal circulation
no smoking.
Exclusion Criteria
pregnancy or an actual wish for pregnancy
lactation period
less than a year in the postmenopausal state
HbA1c > 11%
at random glucose level more than 12 mmol/l at time of FGDPET scan.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>1. Assessment of FDG uptake by PET imaging along plaques in the distal<br /><br>vasculature of the lower limbs that is compared with presence of<br /><br>atherosclerotic lesions within the same individual (as determined by<br /><br>conventional CT scanning).<br /><br>2. Difference in the distribution of FDG uptake by endothelium (at baseline vs.<br /><br>after temporary occlusion by use of a tourniquet for 3 minutes) for each<br /><br>predefined segment along the distal vasculature. </p><br>
- Secondary Outcome Measures
Name Time Method <p>1. To evaluate whether FDG uptake significantly correlates to vascular plaques<br /><br>on CT<br /><br>2. To evaluate whether a FDG PET-derived ischemic border zone correlate with<br /><br>conventional clinical scores of ischemia</p><br>