Effect of fixed appliance on dental biofilm cariogenicity in Thai orthodontic patients

Phase 2

Completed

• Conditions: The healthy subjects ( more than 12 years old) who are undergoing orthodontic treatments.; Fixed orthodontic appliances, dental biofilm, cariogenicity, virulence genes, dental caries

• Registration Number: TCTR20220829007
• Lead Sponsor: Walailak University, International College of Dentistry

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2021-11-18
• Study Start: 2022-08-29
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

The healthy subjects (more than 12 years old) who are undergoing orthodontic treatments at the Advanced Oral Health Center, Walailak University.

Exclusion Criteria

1. Having a systemic disease, 2. On a long term/recent/current regimen of medications affecting salivary flow, 3. Receiving antibiotic therapy within the previous 6 months, 4. Presence severe periodontal problems.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cariogenic virulence gene expressions Before and after at least 6 months of intervention Real time PCR

Secondary Outcome Measures

Name	Time	Method
Dental biofilm maturity Before and after at least 6 months of intervention Three-tone plaque disclosing gel staining