Biomarkers of shear-stress and wall tension in thoracic aortic aneurysms

• Conditions: I71.2; I35.1; Thoracic aortic aneurysm, without mention of rupture; Aortic (valve) insufficiency

• Registration Number: DRKS00004866
• Lead Sponsor: niversity Heart Center Freiburg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2013-04-11
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Age 15-75 years, bicuspid or tricuspid aortic valve, non-syndromic patients, all types of Marfan- or Loeys-Dietz-Syndrome, all Stanford-Fazel clusters of bicuspid aortic valve-associated aortopathy, all Sievers-classes of bicuspid aortic valve, aneurysm of the aortic root, ascending aorta or aortic arch, aneurysm etiologies: degenerative, calcified, Syndrome-associated

Exclusion Criteria

Children with congenital aortic valve vitium or under 15 years of age,
age over 75 years,
connective tissue diseases other than Marfan- or Loeys-Dietz-Syndrome,
Stanford Type A or B aortic dissection,
active malign disease,
congenital plasmatic coagulation disorders,
prior aortic valve replacement,
prior thoracic aortic stengrafting (TEVAR),
prior conventional thoracic aortic prosthetic replacement,
aneurysm etiologies: chronic dissecting, infectious, luetic, false aneurysms, isolated sinus valsalva aneurysm

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Shear-stress and wall-tension in thoracic aortic aneurysms using flow-sensitive magnetic resonance imaging before operative procedure

Secondary Outcome Measures

Name	Time	Method
Serum levels of aortic media-associated structural and functional proteins before operative procedure