Comparing the efficacy of different concentrations of Ropivacaine(0.2%,0.33%,0.5%) with Dexamethasone as an adjunct used in scalp nerve block in relation to Post-operative analgesia and Intra-operative Haemodynamics in patients undergoing elective craniotomy- A Randomized Double Blind study

Dr BASUNDHARA CHAKRABARTI0 个研究点目标入组 0 人开始时间: 待定最近更新: 2023年6月26日

试验速览

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•Patients scheduled for elective craniotomy under general anesthesia planned for on-table extubation and expected to gain consciousness within 2 hrs.
•1) American Society of Anaesthesiologists (ASA) physical
•status of Iâ??II;
•2) Age 18â??60 years;
•3) Participants required to fix their head in a head clamp
•intraoperatively;
•4) Participants with an anticipated full recovery within 2
•hrs postoperatively.

•1) History of craniotomy;
•2) Expected delayed extubation or no plan to extubate;
•3) Participants who cannot understand the instructions
•of a numeral rating scale (NRS) before surgery;
•4) Extreme body mass index (BMI) ( <15 or >35); and body weight <50kg.
•5) Allergy to opioids, dexamethasone, or ropivacaine;
•6) History of excessive alcohol or drug abuse, chronic
•opioid use (more than 2 weeks), or use of drugs with
•confirmed or suspected sedative or analgesic effects;
•7) History of psychiatric disorders, uncontrolled epilepsy
•or chronic headache;
•8) Pregnant or at breastfeeding;
•9) Symptomatic cardiopulmonary, renal, or liver dysfunction
•or history of diabetes;
•10) Preoperative Glasgow Coma Scale <15;
•11) Suspicion of intracranial hypertension;
•12) Peri-incisional infection;
•13) Participants who have received radiation therapy and
•chemotherapy preoperatively or with a high probability
•to require a postoperative radiation therapy and chemotherapy according to the preoperative imaging.

发起方

Dr BASUNDHARA CHAKRABARTI